Oral biological film dynamic model device and its oral biological film forming method

Abstract

The dynamic oral cavity biomembrane model device includes an alkali liquor tank, a culture medium tank, a fermenting tank, a constant flow culture chamber and a sample applying bottle. It features the constant flow culture chamber comprising several serially connected vertical standard cylindrical constant flow culture chambers, the alkali liquor tank connected through peristaltic pump P1 to the fermenting tank, the culture medium tank connected peristaltic pump P2 to the fermenting tank, the fermenting tank with N2 and CO2 introduction through filter F2 and peristaltic pump P4 and waste liquid and waste gas exhaust through peristaltic pump P5 and filter F1, the constant flow culture chamber connected through peristaltic pump P6 to the fermenting tank and with waste liquid and waste gas exhaust through peristaltic pump P7 and filter F3, and the culture medium tank and the sample applying bottle connected through peristaltic pumps P2 and P3 to the constant flow culture chamber.

Description

1. Technical Field [0001] The invention relates to an oral biofilm dynamic model device and a method for forming an oral biofilm, belonging to the field of biofilm oral medical model instruments or oral medicine. 2. Background technology [0002] As a single-celled life form, bacteria have always used the single-cell state free in liquid culture as the research object in long-term research, which simplifies the influence of the external environment to the greatest extent and has obtained a lot of research results. Laid the foundation for modern microbiology. However, in the natural state, bacteria rarely exist in this free form in pure culture. Biofilm is the most common form of survival of bacteria. It refers to a microbial ecological environment formed by a large number of microorganisms on the surface of a solid organic or inorganic medium, gathered in a matrix composed of extracellular polysaccharides and cross-linked with each other. [0003] In the medical field, biofilm di...

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Problems solved by technology

On this basis, a dynamic model device of oral biofilm and a method for forming oral biofilm were developed, which realized continuous and real-time detection of artificial plaque biofilm and obtained a large number of meaningful experimental results, which provided a basis for the diagnosis and treatment of dental caries. Etiology and pathogenesis, screening of anti-caries drugs, evaluation of drug anti-caries efficacy and research on the mechanism of drug action provide a powerful technical platform, but no similar literature reports have been found after searching

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