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Medicine composition containing borneol and musk

A composition and drug technology, applied in the directions of drug combinations, medical preparations containing active ingredients, active ingredients of hydroxyl compounds, etc., can solve problems such as ineffectiveness, and achieve the effect of comprehensive therapeutic effect

Active Publication Date: 2006-11-08
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Surprisingly, when borneol or peony were combined with other active ingredients (such as Danshen), neither the combination of "borneol + danshen" or "peony + danshen" had the effect of the combination of "borneol + peony + danshen"

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0146] Example 1 tablet

[0147] Take Radix Paeoniae Rubra, crush it into a coarse powder, add 80-90% ethanol to reflux and extract three times, combine the extracts, concentrate under reduced pressure and extract three times with n-butanol, 600ml each time, combine the n-butanol extracts, concentrate under reduced pressure to nothing n-butanol flavor, add 400ml of water, heat to dissolve, filter, and spray-dry the filtrate to obtain Extract I for later use;

[0148] Natural borneol 0.5g is crushed into fine powder, and CO with 6g extract I, 3g musk and salvia 2 Supercritical extract 15g (ethanol is entraining agent) is mixed, add auxiliary material (5% of total weight) low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, according to standard granulation and tabletting Process preparation.

Embodiment 2

[0149] Example 2 tablet

[0150] Get Pueraria root total flavonoids extract 13g, natural borneol 2g and grind into fine powder, mix with 10g extract I and 15g musk, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, according to standard Granulation and tableting process to prepare 1000 grains.

Embodiment 3

[0151] Embodiment 3 soft capsules

[0152] Get paeoniflorin 2g, borneol cyclodextrin inclusion complex 25g (containing borneol 2.5g), musk CO 2 Mix 4 g of supercritical extract and 0.5 g of ginkgolide with glycerin, and make 1000 pellets to obtain soft capsules.

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PUM

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Abstract

The present invention relates to medicine composition, and especially one medicine composition containing natural plant extract or element and developed based on modern medical theory and its preparation process and application. The medicine composition contains musk and peony as main components, and is used in treating coma, cardiac and cerebral vascular diseases, senile dementia, diabetes and other diseases.

Description

technical field [0001] The invention relates to a pharmaceutical composition, specifically, a pharmaceutical composition containing borneol, musk and natural plant extracts or monomers developed according to modern medical theory and its application. Background technique [0002] Borneol and musk are commonly used representatives of aromatic and resuscitating traditional Chinese medicines. [0003] There are two types of borneol: natural borneol and synthetic borneol. Among them, borneol borneol is mainly D-borneol, which is the authentic product in borneol, and Ai tablet is mainly L-borneol, while synthetic borneol also contains a large amount of epimers of borneol, isoborneol, in addition to borneol. Musk is also divided into two types: natural and synthetic. At present, due to the restrictions of laws and regulations, most of the medicines use artificial musk. The main components are glycoproteins such as muskone, androsterone, musk-1, cholesterol, etc. (Liu Yangfeng, J...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K31/045A61K31/12A61K31/192A61K31/704A61K31/7048A61P9/10
Inventor 林艳和
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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