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Preparing method of blood circulation promoting injection

A technology of injection and Shuxuetong, which is applied in the field of medicine, achieves the effects of simple production process, reduced production cost and shortened production cycle

Inactive Publication Date: 2006-11-08
西安天一生物技术股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the publication number is CN1660145A, the invention name is "a new preparation method of Shuxuetong freeze-dried powder injection" and the publication number is CN1651079A, the invention name is "a Shuxuetong freeze-dried powder preparation and its preparation method", But these methods also all need to be produced under low temperature, there is same defect to a certain extent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 injection

[0028] 1) The weight ratio of raw materials is: leech 500g, earthworm 500g.

[0029] 2) Take leeches and earthworms, mix them well, soak them in about 500ml of normal saline for about 2 hours, make their surfaces fully spread out, rinse them with normal saline, add 500ml of normal saline and mash them into a homogenate to get leeches and earthworms mixture;

[0030] 3) Get the mixture of leeches and earthworms, add physiological saline to decoct 2 times, the amount of physiological saline added each time is 3.5 times of the mixture of leeches and earthworms, extract for 2 hours each time, combine the extracts, concentrate under reduced pressure to About 1000ml, add 1 times the amount of ethanol, stir well, refrigerate for 15 hours, filter, recover ethanol under reduced pressure, and obtain filtrate A;

[0031] 4) Take filtrate A, add 0.5% activated carbon of the filtrate to decolorize, filter to obtain filtrate B;

[0032] ...

Embodiment 2

[0034] The preparation of embodiment 2 injection

[0035] 1) The weight ratio of raw materials is: leech 600g, earthworm 400g.

[0036] 2) Take leeches and earthworms, mix them evenly, soak them in 800ml of water for about 3 hours, make the surface fully spread out, then rinse them with water, add 600ml of water and mash them into a homogenate to obtain a mixture of leeches and earthworms;

[0037] 3) Take the mixture of leeches and earthworms, add water to decoct 3 times, each time add water twice the amount of the mixture of leeches and earthworms, extract for 1 hour each, combine the extracts, concentrate under reduced pressure to about 800ml, add 2 times Measure ethanol, stir well, refrigerate for 4 hours, filter, recover ethanol under reduced pressure, and obtain filtrate A;

[0038] 4) Take filtrate A, add 0.3% activated carbon of the filtrate to decolorize, filter to obtain filtrate B;

[0039] 5) Take filtrate B and pass through an ultrafiltration column with a molec...

Embodiment 3

[0041] The preparation of embodiment 3 freeze-dried powder injection

[0042] 1) The weight ratio of raw materials is: leech 500g, earthworm 500g.

[0043] 2) Take the leeches and earthworms, mix them evenly, soak them in 600ml of normal saline for 2 hours, make the surface fully spread out and rinse them with normal saline, then add 500ml of normal saline and mash them into a homogenate to get a mixture of leeches and earthworms;

[0044] 3) Take the mixture under item 2), heat and extract twice at 100°C, add 4 times the amount of normal saline each time, extract for 2 hours, combine the extracts, concentrate under reduced pressure to 1200ml, add 1200ml of ethanol, stir well, and refrigerate for 16 hour, filtered, and reclaimed ethanol under reduced pressure to obtain filtrate A;

[0045] 4) Take filtrate A, add 0.8% activated carbon of the filtrate to decolorize, filter to obtain filtrate B;

[0046] 5) Take filtrate B and pass through an ultrafiltration column with a mole...

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Abstract

The present invention is preparation process of blood circulation promoting injection. Medicine material including leech and earthworm is heated to obtain the effective parts, and the effective parts are treated through decolorizing and ultrafiltering to obtain the blood circulation promoting injection. The preparation process is simple, short in preparation period, low in cost and suitable for industrial production, and the prepared injection has required pharmaceutical effect.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a method for preparing traditional Chinese medicine injections by using traditional Chinese medicine leech and earthworm as raw materials. Background technique [0002] Cardiovascular and cerebrovascular disease is a serious disease that endangers people's life and health. Its incidence rate, disability rate and case fatality rate all account for the first of all kinds of diseases. Due to environmental pollution, changes in eating habits, and the accelerated pace of life, the incidence of cardiovascular and cerebrovascular diseases in my country is on the rise, and the population of patients is getting younger. At present, the traditional Chinese medicine preparations used clinically for the treatment of cardiovascular and cerebrovascular diseases are mainly oral preparations. Although oral preparations have certain curative effects, due to absorpt...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/14A61K9/19A61K35/62A61P9/10
Inventor 陈志成杨广德
Owner 西安天一生物技术股份有限公司
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