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Liquid medicine preparation and its preparing process and use

A technology of liquid medicaments and uses, applied in the field of medicine, can solve problems such as solution precipitation and difficulties, and achieve the effect of increasing operating procedures, simple preparation methods, and strict medicinal safety

Active Publication Date: 2006-11-08
无锡新融和药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But in solving the problem of solution precipitation and decomposition, it is very difficult
Because the inventors have found that sodium ferricyanide is made into a solution, even if it is made into a solution according to the method of JP7126017, under short-term intense high-temperature conditions, such as heating at 100°C for 2 hours, precipitation is not easy to occur; but, Regrettably, if the prepared sodium nitroferricyanide solution is stored for a long time at room temperature or slightly higher temperature, such as 2 months at 25°C or 1 month at 40°C, the solution will produce obvious precipitation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1: Injectable liquid medicament containing sodium nitroferricyanide

[0076] Prescription (according to 1000ml):

[0077] Sodium ferricyanide 25g

[0078] 1,2-propanediol 400ml

[0079] Add absolute ethanol to 1000ml.

[0080] Preparation:

[0081] Under the condition of meeting the GMP requirements for pharmaceutical manufacturing, take the prescribed amount of sodium ferricyanide nitrous, add 400ml of propylene glycol and 200ml of absolute ethanol, stir to dissolve, then add ethanol to 1000ml, and stir evenly.

[0082] Filter through a 0.22 μm microporous membrane until the solution is clear, fill the filtrate into brown ampoules, each with 2ml, fill with nitrogen, seal, and sterilize at 100°C for 15 minutes to make an injection containing sodium nitroferricyanide.

Embodiment 2

[0083] Embodiment 2: Injectable liquid medicament containing sodium nitroferricyanide

[0084] Prescription (according to 1000ml):

[0085] Sodium ferricyanide 25g

[0086] Absolute ethanol 300ml

[0087] Add polyethylene glycol-300 to 1000ml.

[0088] Preparation:

[0089] Under the condition of meeting the GMP requirements for pharmaceutical manufacturing, take the prescribed amount of sterile, pyrogen-free sodium ferricyanide nitrous, add 300ml of absolute ethanol, stir to dissolve, then add polyethylene glycol to 1000ml, and stir evenly.

[0090]Filter through a 0.22 μm microporous membrane until the solution is clear, fill the filtrate into brown ampoules, each containing 2ml, fill with nitrogen, seal, and sterilize at 110°C for 15 minutes to make an injection containing sodium ferricyanide.

Embodiment 3

[0091] Embodiment 3: the liquid medicament containing sodium ferricyanide

[0092] Prescription (according to 1000ml):

[0093] Sodium ferricyanide 25g

[0094] Absolute ethanol 600ml

[0095] Glycerin was added to 1000ml.

[0096] Preparation:

[0097] Under the condition of meeting the GMP requirements of pharmaceutical manufacturing, take the prescribed amount of sodium nitroferricyanide, add 600ml of absolute ethanol and 200ml of glycerin, stir to dissolve, add 0.4g of activated carbon, then add glycerin to 1000ml, and stir evenly.

[0098] Filter through a 0.45 μm microporous membrane until the solution is clear, fill the filtrate into brown ampoules, each containing 2ml, fill with nitrogen, seal, and sterilize at 110°C for 15 minutes to make an injection containing sodium ferricyanide.

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PUM

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Abstract

The present invention belongs to the field of medicine technology, relates to liquid medicine for injection, and is especially one kind of liquid medicine for injection containing sodium nitrosoferricyanate and its preparation process and application in preparing intravenous injection medicine. Compared with available technology, the liquid medicine of the present invention has the features of being stable, effective and safe.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and relates to a liquid medicament for injection, in particular to a liquid medicament for injection containing sodium nitroferricyanide, a preparation method of the liquid medicament, and the use of the liquid medicament in Application in the preparation of intravenous drugs. 【Background technique】 [0002] Sodium Nitrosferricyanide (Sodium Nitroprusside, Sodium Nitrosferricyanide, Sodium Nitrosferricyanide Dihydrate, Sodium Nitroprusside, Na 2 [Fe(CN) 5 NO]·2H 2 O) is a fast-acting and short-acting vasodilator. It has a direct expansion effect on arterial and venous smooth muscle, but does not affect the contraction of the uterus, duodenum or myocardium. Vasodilation reduces peripheral vascular resistance and thus has a hypotensive effect. Vasodilation reduces the preload and afterload of the heart and improves cardiac output, so it is beneficial to heart failure. Reduction of afterloa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61K9/08A61K47/10A61P9/04A61P9/12
Inventor 周华英
Owner 无锡新融和药业有限公司
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