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Positioning composition for oral liquid and its preparation

A new type of preparation technology, applied in the field of medicine, can solve the problems such as patents or patent applications for oral preparations that have not yet been seen

Inactive Publication Date: 2006-11-01
SHANTOU UNIV MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Tα has not yet been seen 1 Patents or patent applications for oral formulations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Tα 1 100mg

[0038] Phosphate buffer 10ml

[0039] Acrylic resin No. II 5.0g

[0040] Proper amount of ethanol

[0041] Gelatin solution 50ml

[0042] Enteric-coated microspheres were prepared according to the above basic preparation method, and the prepared microspheres were observed for morphology and tested for their anti-acid ability and enteric-coating ability. The results are shown in Table 1.

Embodiment 2

[0044] Tα 1 100mg

[0045] Phosphate buffer 10ml

[0046] Hypromellose Phthalate 5.0g

[0047] Proper amount of ethanol

[0048] Gelatin solution 50ml

[0049] Enteric-coated microspheres were prepared according to the above basic preparation method, and the prepared microspheres were observed for morphology and tested for their anti-acid ability and enteric-coating ability. The results are shown in Table 1.

Embodiment 3

[0051] Tα 1 100mg

[0052] Phosphate buffer 10ml

[0053] Cellulose acetate phthalate 5.0g

[0054] Proper amount of ethanol

[0055] Gelatin solution 50ml

[0056] Enteric-coated microspheres were prepared according to the above basic preparation method, and the prepared microspheres were observed for morphology and tested for acid resistance and enteric-coating ability. The results are shown in Table 1.

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PUM

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Abstract

An orally taken medicinal composition of thymosin alpha 1 carried by microspheres features that it can be located in intestinal tract to release the thymosin alpha 1. It is prepared from thymosin alpha 1, acrylic resin as enteric material, polyoxyvinyl laurinol ether and laury azazole ketone.

Description

Technical field: [0001] The invention relates to the field of medicine, and is a kind of thymosin alpha 1 The new formulation of enteric-coated microspheres is a formulation that is released in the small intestine and its preparation method. Background technique: [0002] thymosin alpha 1 (thymosin, referred to as Tα 1 ) is a polypeptide with immune function, which is mostly used in the treatment of viral hepatitis clinically. Its amino acid sequence is -Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr- Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-[Glodstein AL, Low TL, McAdoo M, McClure J, et al. Thymosin alpha1: isolation and sequence analysis of an immunological active thymic peptide. Proc Natl Acad SciUSA, 1977, 74(2): 725-729]. Current Tα 1 There is only one dosage form—powder for injection, which has a single route of administration, which is subcutaneous injection, and due to stability reasons, it has higher requirements for storage conditions a...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K9/20A61K9/48A61P1/16A61P31/14A61P35/00A61P37/02
Inventor 王家权徐小虎于晓军董红梅王晋吕俊耀
Owner SHANTOU UNIV MEDICAL COLLEGE
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