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Method for treating neurasthenia or somatic form disorders and medicinal composition

A technology of somatoform disorders and composition, which is applied in the field of pharmacy, can solve the problems of inaccurate curative effect, reduce the curative effect of various emotional symptoms, etc., and achieve the effect of stable and long-lasting effect, fast onset, and convenient portability

Active Publication Date: 2006-10-25
SHENZHEN AUSA PHARM CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The reason for this is mainly because SSRI drugs only selectively act on the 5-HT system, but do not affect the NE system, which also plays an important role in the occurrence and development of depression, anxiety, irritability and other emotional abnormalities. effect on affective symptoms
At the same time, the efficacy of such drugs on neurotic disorders such as neurasthenia and neurotic depression with a relatively long course is even more uncertain.

Method used

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  • Method for treating neurasthenia or somatic form disorders and medicinal composition
  • Method for treating neurasthenia or somatic form disorders and medicinal composition
  • Method for treating neurasthenia or somatic form disorders and medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Example 1 Prepare reboxetine-sertraline compound tablets (1000 tablets) containing 1 mg reboxetine and 12.5 mg sertraline.

[0075] Formula: Reboxetine 1g

[0076] Sertraline 12.5g

[0077] Lactose 50g

[0078] Microcrystalline Cellulose 50g

[0079] Starch 10g

[0080] Sodium carboxymethyl starch 30g

[0081] Magnesium Stearate 1g

[0082] Preparation method: pulverize 1 g of reboxetine, 12.5 g of sertraline, 50 g of lactose, 50 g of crystal cellulose and 10 g of starch, mix them uniformly, make a soft material with 10% povidone ethanol solution, granulate, dry, For granulation, the granules with a water content of about 3% are uniformly mixed with magnesium stearate, and compressed into tablets with a tablet machine. Each of the prepared compound tablets contains 1 mg of reboxetine and 12.5 mg of sertraline, with a mass ratio of 1:12.5.

Embodiment 2

[0083] Example 2 Prepare reboxetine-sertraline compound tablets (1000 tablets) containing 32 mg reboxetine and 150 mg sertraline.

[0084] Formula: Reboxetine 32g

[0085] Sertraline 150g

[0086] Lactose 50g

[0087] Microcrystalline Cellulose 50g

[0088] Starch 10g

[0089] Sodium carboxymethyl starch 30g

[0090] Magnesium Stearate 1g

[0091] Preparation method: as in the preparation method of Example 1, each of the prepared compound tablets contains 32 mg of reboxetine and 150 mg of sertraline, and the mass ratio thereof is 16:75.

Embodiment 3

[0092] Example 3 Reboxetine-citalopram compound tablets (1000 tablets) containing 4 mg reboxetine and 20 mg citalopram were prepared.

[0093] Formula: Reboxetine 4g

[0094] Citalopram 20g

[0095] Lactose 50g

[0096] Microcrystalline Cellulose 50g

[0097] Starch 10g

[0098] Sodium carboxymethyl starch 30g

[0099] Magnesium Stearate 1g

[0100] Preparation method: As in the preparation method of Example 1, each of the prepared compound tablets contains 4 mg of reboxetine and 20 mg of citalopram, and the mass ratio is 1:5.

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PUM

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Abstract

The present invention relates to a method for curing and preventing neurosism or somatic formal disturbance and its medicine composition. Said invention belongs to the field of pharmacy. Said invention provides a medicine composition containing norepinephrine reuptake inhibitor with medicinal dose or its medicinal salt and selective 5-hydroxytryptamine reuptake inhibitor with medicinal dose or its medicinal salt for preventing and curing neurosism or somatic formal disturbance. The norepinephrine reuptake inhibitor is selected from reboxetine, tomoxetine, amfebutamone, nortriptyline, norimipramine, maprotiline and protiline, and the selective 5-hydroxytryptamine reuptake inhibitor is selected from sertraline, citalopram, s-citalopram, fluoroxeline, paroxetine and fluvoxamine.

Description

technical field [0001] The present invention relates to a method and a pharmaceutical composition for treating neurasthenia or somatoform disorder, wherein the active ingredients contain a norepinephrine reuptake inhibitor or a pharmaceutically acceptable salt thereof and a serotonin reuptake inhibitor or a pharmaceutically acceptable salt thereof . The present invention belongs to the field of pharmacy. Background technique [0002] Neurasthenia (neurasthenia) is a common mental disorder. Chapter 5 of the Tenth Edition of the International Classification of Diseases in 1992 (ICD-10) has descriptions and diagnostic criteria for neurasthenia (F48.0). The definition of neurasthenia in the third edition of the Chinese Classification of Mental Disorders (CCMD-3) revised by the Psychiatric Branch of the Chinese Medical Association in 2003 is as follows: [0003] Neurasthenia (CCMD-3 code: 43.5; ICD-10 code: F48.0): Refers to a neurosis characterized by weakened brain and body ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61K9/52A61K31/137A61K31/5375
Inventor 刘平于多龙海珍李劲彤李华王玉戴成祥陈光亮邢厚恂徐希平
Owner SHENZHEN AUSA PHARM CO LTD
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