Dispersed cefditoren pivoxil tablet and its prepn process

A technology for cefditoren pivoxil and dispersible tablets, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. Good, improve medication compliance, high bioavailability

Inactive Publication Date: 2006-10-18
楼剑波 +1
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, only cefditoren pivoxil tablets are sold in China, so the dosage form is single, which cannot meet the medication needs of different types of patients, especially children, the elderly, and patients who have difficulty taking solid preparations such as tablets. New versions of this product have been developed. It is especially necessary to effectively improve the medication compliance of patients to meet the medication needs of these patients
Cefditoren pivoxil dispersible tablets have not been researched and marketed at home and abroad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dispersed cefditoren pivoxil tablet and its prepn process
  • Dispersed cefditoren pivoxil tablet and its prepn process
  • Dispersed cefditoren pivoxil tablet and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0042] Calculated by preparing 1000 tablets, the composition and proportioning ratio of raw and auxiliary materials are:

[0043] Cefditoren pivoxil 100g

[0044] Microcrystalline Cellulose 50g

[0045] Crospovidone 8g

[0046] Protein sugar 20g

[0047] 3% hypromellose solution appropriate amount

[0048] Magnesium Stearate 1g

[0049] Makes 1000 pieces

[0050] Preparation:

[0051] ① Raw and auxiliary materials pass through a 100-mesh sieve.

[0052] ② Weigh hypromellose, add water to make a 3% solution, and set aside.

[0053] ③Weigh the prescription amount of cefditoren pivoxil, microcrystalline cellulose, protein sugar and half of the prescription amount of crospovidone, mix well, add 3% hypromellose solution to make soft material, and granulate with 20 mesh , air-dried at 60°C, granulated at 24 mesh, added with remaining crospovidone and magnesium stearate, and blended.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to cefditoren pivoxil preparation, and is especially dispersed cefditoren pivoxil tablet suitable for children, old people and patient dysphagia of sensitive organism infection and its preparation process. The dispersed cefditoren pivoxil tablet consists of cefditoren pivoxil in 50-150 weight portions, microcrystalline cellulose in 10-500 weight portions, cross-linking polyvidone in 5-50 weight portions, proteoglycan in 5-50 weight portions, 3 % concentration hypromellose solution in proper amount and magnesium stearate in 0.5-5 weight portions. The preparation process includes sieving material, mixing, pelletizing, drying, pressing into tablet and other steps. The dispersed cefditoren pivoxil tablet has the advantages of fast disintegration in water, good taste, high stability, high bioavailability, etc.

Description

technical field [0001] The invention relates to a new preparation of cefditoren pivoxil, in particular a dispersible tablet of cefditoren pivoxil suitable for children infected with cefditoren pivoxil sensitive bacteria, the elderly and patients unable to swallow solid preparations and a preparation method thereof. Background technique [0002] Cefditoren pivoxil is a fourth-generation cephalosporin drug developed by Meiji Seika Co., Ltd., its chemical structural formula is: [0003] [0004] Molecular formula: C 25 h 28 N 6 o 7 S 3 [0005] Molecular weight: 620.73 [0006] Cefditoren pivoxil English name is cefditoren pivoxil, chemical name: (-)-(6R,7R)-2,2-dimethylpropionyloxymethyl 7-[(Z)-2-(2-amino- 4-thiazolyl)-2-methoxyiminoacetamido]-3-[(Z)-2-(4-methyl-5-thiazolyl)ethenyl]-8-oxo-5-thia -1-Azabicyclo[4,2,0]octyl-2-carboxylate has a wide range of antibacterial effects on G+ and G- bacteria, especially Staphylococcus, Streptococcus including Streptococcus pne...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/546A61K9/20A61K47/38A61P31/04
Inventor 楼剑波任燕
Owner 楼剑波
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap