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Preparation process of chromium glucosaminic acid and use thereof

A technology of glucosamine and glucosamine, which is applied in the field of chromium glucosamine, and can solve the problems of obtaining a single purified product, such as complicated operation

Inactive Publication Date: 2006-10-11
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its products are obtained through oxidation-reduction reactions, and operations such as obtaining a single purified product are more complicated

Method used

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  • Preparation process of chromium glucosaminic acid and use thereof
  • Preparation process of chromium glucosaminic acid and use thereof
  • Preparation process of chromium glucosaminic acid and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Embodiment 1 Synthesis of chromium trisamine gluconate (III)

[0039] 1.17 g (6 mmol) of glucosamine acid was dissolved in 12 ml of water, and 6 ml containing 0.5 g of Cr 2 (SO 4 ) 3 ·6H 2 O (1 mmol) in water, stirring and heating the solution to 45°C. In 1.5 hours, slowly add 30 ml containing 0.514 g Ba(OH) 2 (3 mmol) solution. Precipitation was formed immediately, and the solution color changed from green to purple. After continuing to stir for half an hour, the precipitate was filtered off, and the solution was stirred for another 3 hours. The solution was concentrated to 2 / 3 of the original volume, and methanol was added to precipitate a precipitate. The precipitate was filtered off and washed with methanol and ether. Dissolve with the least amount of water, and then add five times the amount of methanol for recrystallization. The precipitate was filtered off and dried in a phosphorus pentoxide dryer. Yield 60%. Elemental analysis, Cr (C 6 h 12 NO 6 ) ...

Embodiment 2

[0040] Embodiment 2 Synthesis of chromium trisamine gluconate (III)

[0041] The amount of reagent used is the same as in Example 1, and the order of addition is adjusted to: first mix glucosamine and barium hydroxide Ba(OH) 2 After stirring the solution at 45°C, add chromium sulfate Cr 2 (SO 4 ) 3 ·6H 2 O aqueous solution. Subsequent processing is carried out with embodiment 1. Combine spectral analysis through elemental analysis, identical with embodiment 1 product.

Embodiment 3

[0042] Example 3 Trisamine gluconate dichromium (III) hydrochloride

[0043] 1.960 g (10 mmol) of glucosamine acid was dissolved in 20 ml of water, and 15 ml containing 1.251 g of Cr 2 (SO 4 ) 3 ·6H 2 O (2.5 mmol) in water, stirring and heating the solution to 45°C. In 1.5 hours, slowly add 50 ml containing 0.857 g Ba(OH) 2 (5 mmol) and 0.611 g of BaCl 2 (2.5 mmol) solution. Precipitation was formed immediately, and the solution color changed from green to purple. After continuing to stir for half an hour, the precipitate was filtered off, and the solution was stirred for another 3 hours. The solution was concentrated to 2 / 3 of the original volume, and methanol was added to precipitate a precipitate. The precipitate was filtered off and washed with methanol and ether. Dissolve with the least amount of water, and then add five times the amount of methanol for recrystallization. Yield: 35%. Elemental Analysis: Cr 2 (C 6 hi 2 NO 6 ) 3 Cl 3 Theoretical value: C 27....

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Abstract

The invention relates to chromium amino gluconate (III) having a molecular formula of Crn(C6H12NO6)3Ap, n=1 or 2, its preparing process and use, wherein the compound is obtained through the reaction between amino glucose acid, chromic sulfate and barium hydroxide in solution. The compound can be used as highly effective replenisher for trace elements in human body and for the treatment of high blood sugar.

Description

technical field [0001] The invention relates to chromium glucosamine and its preparation method and application, in particular to chromium glucosamine with hypoglycemic effect. Background technique [0002] In 1959, Schwartz established the theory that the human body must supplement trivalent chromium trace elements in the diet. Chromium picolinate or PicCr (US Patent US RE33988) is an organic compound of trivalent chromium, which was discovered by Dr. Anderson of the United States to enhance insulin sensitivity (Andersion, Clin.Psychol.Biochem.4: 31-41, 1986), chromium also has an effect on cell receptors, although its mechanism of action is still unclear, but chromium deficiency can lead to disorders of sugar, lipid body, and protein metabolism, and is also related to diabetes and cardiovascular diseases , chromium is a synergistic factor of insulin, and chromium has been recognized as having a great relationship with the activity of insulin (Boyle et al., Southern Med.i....

Claims

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Application Information

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IPC IPC(8): C07H23/00A61K31/7135A61P3/10C07F11/00C07H5/06
Inventor 白志平段春迎区升举陈光林志华赵永刚张丙广
Owner NANJING UNIV
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