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Redfish calcitonin inhalation powder-atomizing agent and preparing method

A salmon calcitonin and powder spray technology, applied in the field of pharmaceutical preparations, can solve the problems of patient inconvenience, inability to form, loss, etc., and achieve the effects of good atomization performance, not easy to absorb moisture, and stable quality

Inactive Publication Date: 2006-08-09
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the main route of administration of calcitonin is injection. Since patients need long-term medication, long-term injection will bring a lot of inconvenience and pain to patients.
CN1370523A discloses the nasal powder inhalation of salmon calcitonin, which is composed of methylcellulose, surfactants, diluents, etc., and achieves therapeutic effect through nasal mucosal absorption, but long-term use of surfactants can damage nasal mucosal cells, In addition, nasal administration has disadvantages such as inaccurate quantification, uneven distribution of drug powder in the nasal cavity, and easy loss from the nasal cavity.
But there are also particles that are prone to adhesion and aggregation, making the body system unstable, etc. Therefore, it is still impossible to form a technical solution suitable for industrialized production (preparation and pharmaceutical properties of salmon calcitonin inhalation powder spray such as Xiong Lianjie) Research, "Acta Pharmaceutica Sinica" 2003, 38(3): 218-222)

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Add 17.0 g of mannitol and 8.0 g of leucine to about 200 ml of water to dissolve, add 0.03 g of salmon calcitonin, then add water to 1600 ml, filter with a 0.2 μm microporous membrane, and spray dry. The conditions are that the inlet temperature is 110°C, the outlet temperature is controlled between 70-75°C, the cyclone speed is 90%, and the nozzle air flow rate is 800ml / min. The white salmon calcitonin powder was obtained, the content of salmon calcitonin was determined, and the powder was divided into hard capsules. The prepared powder aerosol has a bulk density of 0.18, an angle of repose of 38.8°, and a powder residue of the capsule shell of 3.7%. There are a small amount of fine particles in the sediment during the atomization test, and the atomization effect is qualified.

Embodiment 2

[0096] Add 12.0 g of mannitol and 13.0 g of leucine to about 200 ml of water to dissolve, add 0.03 g of salmon calcitonin, then add water to 1600 ml, filter with a 0.2 μm microporous membrane, and spray dry. The conditions are that the inlet temperature is 110°C, the outlet temperature is controlled between 70-75°C, the cyclone speed is 90%, and the nozzle air flow rate is 800ml / min. The white salmon calcitonin powder was obtained, the content of salmon calcitonin was determined, and the powder was divided into hard capsules. The prepared powder aerosol has a bulk density of 0.12, an angle of repose of 36.2°, and a powder residue of the capsule shell of 3.5%. There are very few fine particles in the sediment during the atomization test, and the atomization effect is better.

Embodiment 3

[0098] Add 10.0 g of mannitol and 15.0 g of leucine to about 200 ml of water to dissolve, add 0.03 g of salmon calcitonin, then add water to 1600 ml, filter with a 0.2 μm microporous membrane, and spray dry. The conditions are that the inlet temperature is 110°C, the outlet temperature is controlled between 70-75°C, the cyclone speed is 90%, and the nozzle air flow rate is 800ml / min. The white salmon calcitonin powder was obtained, the content of salmon calcitonin was determined, and the powder was divided into hard capsules. The prepared powder aerosol has a bulk density of 0.10, an angle of repose of 35.1°, and a powder residue of the capsule shell of 2.9%. During the atomization test, the powder can form smoke and deposit uniformly. No granular aggregates are seen, and the atomization effect is optimal.

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PUM

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Abstract

The invention relates to drug manufacturing field, especially a trout calcitonin powder fog agent and the manufacturing method. It is made up from 3 portions of trout calcitonin, 500-2000 portions of mannitol, and 500-2000 portions of amino acid. It has good solubleness, bulk density, sprayabiligy, and is not easy to absorb moisture.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a salmon calcitonin powder spray and a preparation method thereof, in particular to a salmon calcitonin powder spray that can be inhaled through the mouth and then absorbed in the lungs to exert medicinal effects and a preparation method thereof . Background technique [0002] Calcitonin is a polypeptide hormone secreted by thyroid follicular cells that regulates calcium and phosphorus metabolism. It consists of 32 amino acids. It was discovered by Copp et al. in 1961 and further proved by Kumar and Foster et al. in 1963. The amino acid residues of calcitonin secreted by different animals have certain differences, and the biological activity of calcitonin secreted from fish is more than 50 times stronger than that of calcitonin secreted from mammals. At present, there are four kinds of calcitonin: calcitonin (HCT), calcitonin (PCT), salmon calcitonin (sCT) and eel calc...

Claims

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Application Information

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IPC IPC(8): A61K38/23A61K9/12A61K9/48A61P19/10
Inventor 朱家壁张旭松
Owner CHINA PHARM UNIV
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