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Saflor yellow pigment rich in saflor yellow pigment B, its preparation method and use

A technology of safflower yellow and safflower, which is applied in the field of safflower yellow and its preparation, can solve the problems that the preparation method and application have not been reported yet, and achieve the effects of low cost, high separation efficiency and increased utilization times

Inactive Publication Date: 2006-06-14
SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Liu Ke prepared safflower yellow rich in hydroxyl safflower yellow A by macroporous resin method [CN 1368503A]; Li Guisheng prepared safflower yellow A and safflower yellow B rich in Total flavonoids of flowers [CN 1429830A]; Jin Ming prepared hydroxysafflower yellow A by macroporous resin method [Jin Ming, preparation of safflower yellow and hydroxysafflower yellow A by macroporous resin column chromatography, Chinese herbal medicine, 2004, 1: 25-28]; but the safflower yellow rich in safflower yellow B and its preparation method and application have not been reported yet. The inventors have provided a kind of safflower yellow B rich Safflower yellow pigment and its preparation method and use

Method used

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  • Saflor yellow pigment rich in saflor yellow pigment B, its preparation method and use

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Experimental program
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Effect test

Embodiment 1

[0031] Take 20kg of safflower medicinal material, add 8 times the amount of water, heat and decoct for 2 hours, then filter, take the filtrate and concentrate to a density of 1.15; add ethanol to the concentrated solution until the alcohol concentration is 80%, alcohol precipitation at room temperature or 4°C for 24 hours, centrifuge to remove the precipitate, take the supernatant, evaporate the ethanol under reduced pressure until there is no alcohol smell; add 5 times of water to the concentrated solution, precipitate at 4°C for 24 hours, and centrifuge to remove the precipitate; take the above supernatant on DM- 130 macroporous resin, eluted with 15% ethanol for 5 column volumes, discarded; continued to elute with 50% ethanol for 8 column volumes; Elute 5 column volumes, discard, and then elute 5 column volumes with 95% ethanol solution, collect the eluate, concentrate until it has no alcohol smell, and dry to obtain safflower yellow, which is measured by HPLC. The content ...

Embodiment 2

[0033] Take 20 kg of safflower medicinal material, add 15 times the amount of water to soak for 24 hours, then filter, take the filtrate and concentrate to a density of 1.05; add ethanol to the concentrated solution until the alcohol concentration is 80%, alcohol precipitation at room temperature or 4°C for 24 hours, Remove the precipitate by centrifugation, take the supernatant, evaporate ethanol under reduced pressure until there is no alcohol smell; add 8 times of water to the concentrated solution, precipitate at 4°C for 24 hours, and remove the precipitate by centrifugation; take the above supernatant and put it on AB-8 large Pore ​​resin, elute with 5% ethanol for 8 column volumes, discard; continue to elute with 30% ethanol for 3 column volumes; collect the above eluate and load it on the treated polyamide column, and first elute with 60% ethanol 3 column volumes were discarded, and 8 column volumes were eluted with 95% ethanol solution, and the eluate was collected and ...

Embodiment 3

[0035] Take 20kg of safflower medicinal material, add 12 times the amount of water to soak for 12 hours, then filter, take the filtrate and concentrate to a density of 1.10; add ethanol to the concentrated solution until the alcohol concentration is 80%, alcohol precipitation at room temperature or 4°C for 12 hours, Remove the precipitate by centrifugation, take the supernatant, evaporate ethanol under reduced pressure until there is no alcohol smell; add 3 times water to the concentrated solution, precipitate at 4°C for 24 hours, and remove the precipitate by centrifugation; take the above supernatant and put it on D-101 large Pore ​​resin, eluted with 15% ethanol for 3 column volumes, discarded; continue to elute with 50% ethanol for 8 column volumes; collect the above eluate and load it on the treated polyamide column, and first elute with 60% ethanol 8 column volumes, discarded, and then eluted with 80% ethanol solution for 5 column volumes, collected the eluate, concentrat...

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Abstract

The present invention relates to a carthamus yellow richly containing carthamus yellow B, in which the carthamus yellow B content is greater than or equal to 80% and less than 100%, the optimized content is greater than or equal to 90% or less than 100%. Said invention also relates to its preparation method and medicine composition containing said carthamus yellow. Said invention also provides its application in preparation of medicine for preventing and curing ischemic brain injury.

Description

technical field [0001] The invention relates to a safflower yellow rich in safflower yellow B, a preparation method and application thereof. Background technique [0002] The safflower Carthamus tinctorius L. of Compositae is a species recorded in the Chinese Pharmacopoeia, and it is a commonly used drug for promoting blood circulation and removing stasis. Clinically, safflower is used in water decoction, the main component of which is safflower yellow pigment, which is a mixed chalcone glycoside [Jin Ming, Li Jinrong, Cai Yaxin, Research on the Antioxidative Effect of Water-soluble Components of Safflower, Cardiopulmonary Vascular Diseases Journal, 1998, 4: 277-279]. In recent years, domestic scholars have carried out in-depth research on the pharmacological effects of safflower yellow, and found that safflower yellow is effective in expanding the crown, lowering blood pressure, antithrombotic, anticoagulant, promoting blood circulation and removing blood stasis, resistanc...

Claims

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Application Information

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IPC IPC(8): C07D309/10A61K31/352A61P9/10
Inventor 张达磊李桂生马成俊刘珂王超云张太平孙芳
Owner SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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