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Oral cavity nursing agent

An oral care agent and active agent technology, applied in the field of oral hygiene, can solve the problems of affecting the oral saliva secretion function, high concentration of quaternary ammonium salts and biguanides, affecting the normal function of the oral cavity, etc., reducing irritation and astringency, and low toxicity. , the effect of increasing oral comfort

Inactive Publication Date: 2006-05-31
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the two patents do not mention the combined use of aluminum compounds and zinc compounds, which has the following disadvantages: the first use of quaternary ammonium salts and biguanides is high in concentration, which increases oral irritation and affects oral saliva secretion function
Although the side effects on the oral cavity are reduced by using weak salts of aluminum or zinc, the effective concentration of aluminum or zinc in the oral cavity is reduced, which affects the drug effect
Therefore, the creators tried to improve the effect of the drug by increasing the dose, but it also inhibited the secretion of saliva in the mouth and affected the normal function of the mouth.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation method of the zinc-aluminum citric acid complex: dissolve 1.0 mol of citric acid in an appropriate amount of water, stir and add 0.05 mol of aluminum oxide and 0.4 mol of zinc oxide until the aluminum oxide and zinc oxide are completely dissolved. with potassium hydroxide

[0053] Adjust the pH to 7.0. Remove water, crystallize to obtain 290g zinc aluminum citrate complex K 19 AlZn 4 (C 6 h 5 o 7 ) 10 .

[0054] Described oral care agent is made up of following components by weight percentage:

[0055] Octadecyldimethylbenzyl ammonium chloride 1.0%

[0056] 1,6-bis(4-chlorophenylbiguanide)hexane dihydrochloride 1.0%

[0057] Nonylphenol polyoxyethylene (OP-10) 10%

[0058] Zinc Aluminum Citrate Complex K 19 AlZn 4 (C 6 h 5 o 7 ) 10 1.5%

[0059] Ethanol 35%

[0060] Trimethyl Citrate 1.5%

[0061] Add water to 100%

[0062] The pH was adjusted to 6.5.

[0063] The methods and steps other than the above can be implemented with refer...

Embodiment 2

[0070] The preparation method of the zinc-aluminum tartaric acid complex: dissolve 0.65 mol of tartaric acid in an appropriate amount of water, stir and add 0.05 mol of aluminum carbonate and 0.4 mol of zinc carbonate until the aluminum carbonate and zinc carbonate are completely dissolved. Adjust the pH to 7.0 with sodium hydroxide. Remove water, crystallize to obtain 128g zinc aluminum tartaric acid complex Na 2 AlZn 4 (C 4 h 4 o 6 ) 6.5 .

[0071] Described oral care agent is made up of following components by weight percentage:

[0072] Tetradecylpyridinium Chloride 0.001%

[0073] 1,6-bis(4-chlorophenylbiguanide)hexane diacetate 0.001%

[0074] Octylphenol polyoxyethylene (OP-10) 0.05%

[0075] Zinc aluminum tartaric acid complex Na 2 ZN 4 (C 4 h 4 o 6 ) 6.5 0.05%

[0076] Butanol 5%

[0077] Tripropyl Citrate 0.1%

[0078] Add water to 100%

[0079] The pH was adjusted to 5.5.

[0080] The oral care agent described in Example 2 was tested for its di...

Embodiment 3

[0086] Preparation method of zinc-aluminum citric acid complex: dissolve 0.65 mol of citric acid in an appropriate amount of water, stir and add 0.05 mol of aluminum carbonate and 0.4 mol of zinc oxide until the aluminum carbonate and zinc oxide are completely dissolved. Adjust the pH to 7.0 with potassium hydroxide. Remove water, crystallize to obtain 183g zinc aluminum citrate complex K 8.5 AlZn4 (C 6 h 5 o 7 ) 6.5 .

[0087] Preparation method of the zinc-aluminum citric acid complex: dissolve 0.4 mol of citric acid in an appropriate amount of water, stir and add 0.1 mol of aluminum hydroxide and 0.1 mol of zinc oxide until the aluminum hydroxide and zinc oxide are completely dissolved. Adjust the pH to 7.0 with sodium hydroxide. Remove water, cool and crystallize to obtain 100g zinc-aluminum citrate complex Na 7 AlZn(C 6 h 5 o 7 ) 4 .

[0088] Described oral care agent is made up of following components by weight percentage:

[0089] Dodecyldimethyl(2-phenoxye...

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PUM

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Abstract

An oral nursing agent contains quaternary ammonium salt, biguanide, non-ionic surfactant, Zn-Al-polyprotic acid composition, hydrophilic solvent, enzyme inhibitor and water. A process for preparing said Zn-Al-polyprotic acid composition is also disclosed.

Description

Technical field: [0001] The invention relates to the field of oral hygiene, in particular to dental preparations, in particular to an oral care agent. Background technique: [0002] The purpose of oral care is firstly to clean the mouth, maintain oral hygiene, and prevent oral infection; secondly, to prevent bad breath and maintain a normal oral odor; thirdly, to prevent tartar formation, keep teeth white and healthy, and prevent dental diseases; finally, to provide a pleasant oral cavity. smell, keep your mouth moist. One of the most important is to suppress and remove bad breath and tartar. [0003] Halitosis is related to oral diseases and the ecological environment of the oral cavity. Oral uncleanness, dental calculus, tartar, and decomposition of oral organic matter are the most direct causes of bad breath. Commonly used oral deodorization methods are as follows: first, use a masking agent to cover up oral odor. For example, using essence or other irritating gas to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/40A61Q11/00
Inventor 刘瑞源
Owner SOUTHERN MEDICAL UNIVERSITY
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