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Application of astragaloside in preparing medication for treating peripheral nervous lesion of diabetes

A technology for peripheral neuropathy and astragaloside IV, which is applied in the field of application of astragaloside IV in the preparation of drugs for treating diabetic peripheral neuropathy, can solve the problems of diabetic peripheral neuropathy that have not been seen with astragaloside IV, and achieve good medicinal prospects , strong effect, lowering blood sugar and glycosylated hemoglobin and promoting insulin secretion

Inactive Publication Date: 2006-04-19
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] But so far there has been no relevant report that astragaloside IV can treat diabetic peripheral neuropathy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Effects of Astragaloside IV (AS-N) on General Physiological Conditions of DPN Rats

[0033] (1). Materials and methods

[0034] 1 experimental animal

[0035] Male Sprague-Dawley rats, weighing 180-210 g, were provided by Shanghai Slack Experimental Animal Co., Ltd., animal certificate number: SCXK (Shanghai) 2003-0003.

[0036] 2 Drugs, reagents and instruments

[0037] Astragaloside IV (AS-IV), with a molecular weight of 784, was extracted from Astragalus membranaceus by Jiangsu Province & Institute of Medicinal Botany, Chinese Academy of Sciences, and the purity of AS I was confirmed to be greater than 99% by normalization method using HPLC. Streptozotocin (STZ) was purchased from Calbiochem, lot number Lot.B51229. The blood glucose detection kit was purchased from Zhejiang Dongou Bioengineering Co., Ltd., lot number Lot2004030266. Insulin radioimmunoassay kit was purchased from China Institute of Atomic Energy, Beijing, lot number Lot20040701. Epalre...

Embodiment 2

[0050] Example 2 Effect of astragaloside IV (AS-IV) on blood sugar and glycosylated hemoglobin in DPN rats

[0051] 1. Materials and methods (with embodiment 1)

[0052] 2 results

[0053] Blood glucose and glycosylated hemoglobin (HbA 1 C) significantly higher than that of the normal control group, with a very significant difference (P1 C Compared with the DPN group, the blood sugar drop was not obvious; while the AS-IV middle and high dose treatment group compared with the DPN group, showed a significant hypoglycemic effect (P1 C also decreased significantly (P<0.05) (see Table 2).

[0054] group

[0055] Note: Compared with the NS group and the DPN group, ## P<0.01; compared with drug treatment group and DPN group, *P<0.05, **P<0.01

Embodiment 3

[0056] Example 3 Astragaloside IV (AS-IV) stimulates insulin secretion in DPN rats

[0057] Insulin-stimulating effect of AS-IV on DPN rats

[0058] The content of plasma insulin in the normal group rats was significantly higher than that in the DPN group (P<0.01), the insulin content in the AS-IV low-dose treatment group was only slightly increased, and the plasma insulin content in the AS-IV middle and high-dose group was significantly higher than that in the DPN group (P<0.01). 0.05), suggesting that AS-IV has the function of promoting insulin secretion. (See Table 3,).

[0059] group

[0060] Note: Compared with the NS group and the DPN group, ## P<0.01; compared with drug treatment group and DPN group, *P<0.05, **P<0.01

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PUM

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Abstract

An application of astragalus saponin A in preparing the medicines for preventing and treating the diabetic peripheral neuropathy is disclosed. Said medicine applied orally is prepared from the astragalus saponin A and proper additive.

Description

1. Technical field [0001] The present invention relates to the new use of astragaloside IV (ASI), in particular to the application of astragaloside IV in the preparation of medicines for treating diabetic peripheral neuropathy. 2. Background technology [0002] According to statistics, there are currently more than 30 million diabetic patients in my country. WHO predicts that by 2025, the number of diabetic patients in China will reach 50 million. my country has become the second largest diabetic country in the world after India. [1] . The harm of diabetes mainly comes from complications, including neuropathy, retinopathy, vascular disease and diabetic nephropathy. Because the energy of nerve cells mainly depends on glucose, the metabolic disorder caused by high blood sugar can easily induce neuropathy; diabetic neuropathy is one of the earliest and highest incidence complications of diabetic complications, and the lesions involve peripheral nerves and Central nervous syst...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P3/10A61P25/02
Inventor 张银娣余俊先孙视沈建平张涵庆刘玥辉
Owner NANJING MEDICAL UNIV
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