Medicine for treating cardio-cerebral vascular diseases and its preparing method

A technology for cardiovascular and cerebrovascular diseases and drugs is applied in the field of drugs for the treatment of cardiovascular and cerebrovascular diseases and their preparation, which can solve problems such as affecting the treatment of diseases, and achieve the effects of no adverse reactions, significant clinical treatment effects, and no toxic effects.

Inactive Publication Date: 2006-03-22
吉林迈迪星药物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, most drugs have great limitations in the treat...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] (1) Take 200g of Tribulus terrestris, 150g of Chuanxiong, and 125g of Panax notoginseng. Pulverize into coarse powder respectively, then add water 20 times of the weight of respective medicines respectively, heat and boil three times, each time for one hour.

[0055] (2) Combine the water extracts obtained from Tribulus terrestris, Rhizoma Chuanxiong and Radix Notoginseng, respectively, and concentrate to a relative density of 1.20 at 50°C;

[0056] (3) Add ethanol to the respective concentrates of Tribulus terrestris, Chuanxiong and Sanqi, respectively, until the alcohol concentration reaches 80%, and place them separately for 24 hours, filter, recover ethanol from the filtrate until there is no alcohol smell, dilute, and filter to obtain Sanqi filtrate , Tribulus terrestris filtrate, Chuanxiong filtrate;

[0057] (4) After the Sanqi filtrate and the Tribulus filtrate are adsorbed by the macroporous adsorption resin column respectively, they are eluted with 75% alcoho...

Embodiment 2

[0065] (1) Take 50g of Tribulus terrestris and 500g of Panax notoginseng and mix them into coarse powder, add 20 times the weight of water, and 50g of Ligusticum chuanxiong, grind them into coarse powder and add 20 times the weight of water, heat and boil for extraction three times, each time for 1 hour.

[0066] (2) The water extracts of Tribulus terrestris and Ligusticum chuanxiong were collected respectively, and concentrated to a relative density of 1.0 at 60°C to obtain concentrates respectively.

[0067] (3) Add ethanol to the concentrated solution of Sanqi and Tribulus terrestris and Ligusticum chuanxiong respectively until the alcohol concentration reaches 60%, leave it for 24 hours, filter, recover the ethanol from the filtrate until there is no alcohol smell, dilute and filter to obtain the filtrate respectively;

[0068] (4) Adsorb the filtrate of Sanqi and Tribulus terrestris through a macroporous adsorption resin column, elute with 70% alcohol, collect the eluate t...

Embodiment 3

[0074] Get 500g of Tribulus terrestris, 50g of Rhizoma Chuanxiong, 500g of Radix Notoginseng, 13g of Borneolum, the active ingredient extraction process is the same as that of Example 1 or 2, the active ingredient that is obtained is added starch in a ratio of parts by weight of 1: 1, and is prepared according to the routine method of tablet Into tablets, 0.3g per tablet.

[0075] Other items should meet the relevant requirements of the tablet items in the Pharmacopoeia of the People's Republic of China 2000 Edition.

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Abstract

The present invention belongs to the field of Chinese medicine technology. The medicine for treating cardiac and cerebral vascular diseases is prepared with puncture vine, Chuanxiong rhizome, notoginseng and borneol, and through crushing puncture vine, Chuanxiong rhizome and notoginseng into coarse powder, water decoction or alcohol extraction, concentrating the extracted liquid, adding alcohol and filtering, adsorption with macroporous resin, elution, concentration, spray drying, crushing, mixing with borneol to obtain the active components, mixing with proper amount of pharmaceutically acceptable carrier or excipient, and preparing into different preparation forms for clinical use. The present invention has obvious curative effect and no toxic side effect and negative effect.

Description

Technical field: [0001] The invention relates to a medicine for treating cardiovascular and cerebrovascular diseases and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. Background technique: [0002] With the progress of society, people's life expectancy is continuously prolonging, followed by an increase in the prevalence of cardiovascular and cerebrovascular diseases such as ischemic stroke (cerebral infarction) or angina pectoris caused by myocardial ischemia, myocardial infarction. In recent years, the mortality rate of cardiovascular and cerebrovascular diseases has always occupied the first place, becoming the number one killer threatening human health. So far, there is no cure for it. In the event of an emergency, emergency medicine such as nitroglycerin is used for rescue, which can only alleviate the clinical symptoms, but cannot cure the disease. Traditional Chinese medicine has made considerable progress in the tr...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61K31/045A61K9/00A61P9/10
Inventor 徐暾海徐东铭刘平徐雅娟
Owner 吉林迈迪星药物科技发展有限公司
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