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Reversible heat gelling aquatic pharmaceutical composition of a Chinese medicine and compound prescription thereof

A technology of thermal gelation and composition, applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc., can solve the problems such as the need for further verification of safety, the influence of salt and the situation of gelation are not studied.

Inactive Publication Date: 2006-02-22
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gelation around body temperature in mammals has not been studied, nor has the effect of specific salts that are applicable
Moreover, the methoxyl content of the methyl cellulose used in this document is relatively high, exceeding the range of 27-32% methoxyl content stipulated in the Chinese Pharmacopoeia, and its safety needs to be further verified.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0249] Take 50g of dense Menghua, 15g of chrysanthemum, 15g of Xu Changqing, extract volatile oil, medicinal residue and 10g of cassia seed, add water and decoct 2 times for 2 hours each time, combine the decoction, filter, concentrate the filtrate, add ethanol to the concentrate to make the alcohol content Reach 75%, alcohol precipitation, refrigerate (-2~2℃) for 24 hours, filter, and the filtrate will recover ethanol until no alcohol taste, add 0.2g of borneol, add 50ml of distilled water, and sink (-2~2℃) for 24 hours, After filtering and adding the above-mentioned volatile components, it is the traditional Chinese medicine extract of the present invention. Separately take 7.6g of sodium citrate and 1.0g of chlorobutanol in the above Chinese medicine extract, dissolve it, add 8.0g of MC100 dissolved in 25ml of sterilized distilled water, stir thoroughly and adjust the pH to 7.0 with citric acid. Make up to 200g of sterilized distilled water, stir thoroughly while cooling the wa...

Embodiment 2

[0251] Take 30g of Cassia Seed, 15g of Qianghuo 15g, 15g of Dense Menghua, 25g of Cassia, 15g of Weilingxian, 10g of Angelica, add water to decoc three times, 1 hour each time, combine the decoction, filter, take the filtrate and concentrate to concentrate, add 3 to 5 times of ethanol is used to precipitate, the recovered ethanol is concentrated to a concentrated solution, 50 ml of water is added, the water is settled (-2 to 2°C) for 24 hours, and filtered to obtain the traditional Chinese medicine extract of the present invention. Take another 10g of sodium triphosphate dissolved in 50ml of sterilized distilled water, adjust pH to 5.0 with citric acid, add 0.01g of benzylammonium chloride, then add 7.0g of MC400 dissolved in 25ml of sterilized distilled water, adjust pH to 5 with citric acid .5, make up to 200g with sterile distilled water, stir and dissolve thoroughly while cooling the water to obtain eye drops.

Embodiment 3

[0253] Take 30g of wild chrysanthemum, 15g of cassia seed, 10g of safflower, 10g of ginseng, add water and decoct twice, 1 hour each time, combine the decoction, filter, take the filtrate and concentrate to concentrate, add 3 times ethanol to precipitate, and recover ethanol Concentrate to a concentrated solution, add 50 ml of water, sink in water (-2 to 2°C) for 24 hours, and filter to obtain the traditional Chinese medicine extract of the present invention. Take another 6g of sodium tartrate, add 50ml of sterilized distilled water and stir thoroughly, adjust the pH to 6.5 with ethanolamine, combine the above two solutions, add 0.02g of benzalkonium chloride, and then add 6g of MC400 dissolved in 50ml of sterilized distilled water. Adjust the pH of ethanolamine to 7.4, make up to 200g with sterile distilled water, stir and dissolve thoroughly while cooling the water to obtain eye drops.

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Abstract

Disclosed is a reversible heat gelling aquatic pharmaceutical composition of a Chinese medicine and compound prescription, wherein the composition comprises traditional Chinese medicines and their compound recipe with various actions, methyl hydroxypropylcellulose of certain density, multiple valency salts of acid and pH regulator. The composition can realize gelatinization within a short period of time.

Description

Technical field: [0001] The invention relates to a reversible thermal gelation aqueous pharmaceutical composition containing a traditional Chinese medicine and its compound components, and a combination of methyl cellulose and a polyvalent acid salt as a matrix, and belongs to the field of traditional Chinese medicine preparations. It is characterized in that the aqueous pharmaceutical composition is a flowable liquid below room temperature or at room temperature. When used in the human body and other mammals in need of treatment, the temperature rises to or close to body temperature, which can achieve coagulation in a short time. Gelation, thus has the effect of prolonging the residence time of the medicinal ingredients at the drug site, increasing the biological availability of the medicinal ingredients, and prolonging the duration of the medicinal effect. Background technique: [0002] According to the investigation and retrieval of relevant information, it is found that the c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K36/00A61K9/00A61P1/02A61P11/02A61P13/02A61P15/02A61P17/00A61P27/00
Inventor 张玲凌沛学张建强董爱梅祝美华张新房尚立霞
Owner 凌沛学
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