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Total secondary ginseng glucoside oral disintegration tablets prepn. method and application thereof

The technology of oral disintegrating tablet and total ginseng secondary glycosides is applied to the oral disintegrating tablet of ginseng total secondary glycosides and its preparation and application fields, which can solve the problems of weak action intensity and the like, and achieves increasing oxygen supply, inhibiting myocardial ischemia, improving The effect of heartbeat power

Inactive Publication Date: 2006-01-11
NAT INST OF PHARMA R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] These secondary saponins have many new activities, for example: ginsenosides Rh1, Rh2, and Rg3 have obvious anticancer activity, can induce redifferentiation of cancer cells, and can induce cancer cells to redifferentiate into healthy cells, while other saponin monomers have No such effect, or weaker effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Take 50g of ginseng total glycosides pharmaceutical composition, take microcrystalline cellulose and mannitol, pulverize respectively, sieve, and set aside; take 15g of methacrylic acid polymer Eudragit E100 type, dissolve it in an appropriate amount of ethanol solution, and slowly add ginseng under stirring condition Total glycosides, continue to stir until the total ginseng glycosides are uniformly dispersed, dry under reduced pressure, pulverize, sieve, add cross-linked polyvinylpyrrolidone 10g, microcrystalline cellulose 70g, mannitol 190g, aspartame 2g, micropowdered silica gel 17.5 g, 1.5g of magnesium stearate, mix well, measure the content, calculate the weight of the tablet, and compress it to get final product.

Embodiment 2

[0121] Ginseng total glycosides pharmaceutical composition 100g, take 0.6g of methacrylic acid polymer Eudragit E type, dissolve in an appropriate amount of ethanol solution, add ginseng total glycosides slowly under stirring conditions, continue to stir until ginseng total glycosides are dispersed evenly, reduce Press dry, pulverize, sieve; add microcrystalline cellulose 12g, croscarmellose sodium 7g, mix evenly, make soft material with water, granulate, dry, granulate, measure content, calculate tablet weight, compress tablet, that is have to.

Embodiment 3

[0123] Take by weighing 50g of ginseng total glycosides pharmaceutical composition, starch 30g, citric acid 55g, tartaric acid 55g, sodium bicarbonate 40g, peppermint essence 5g, cyclamate 15g, micropowder silica gel 45g, talcum powder 5g, mix, measure content, calculate tablet Heavy, pressed into tablets, ready to serve.

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PUM

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Abstract

An oral disintegrating tablet of hypopanaxin for treating the stuffiness and blocking sensation of chest, cardialgia, myocardial ischemia, hemorrhagic shock, etc contains 20-(S)-Rg3, 20-(R)-Rg3, 20-(S)-Rg2, 20-(R)-Rg2, 20-(S)-Rh1, 20-(R)-Rh1 and filler. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing effective parts of ginseng and its preparation method and application, in particular to an orally disintegrating tablet of total ginseng glycosides and its preparation method and application. Background technique [0002] Ginseng is an important medicine for invigorating Qi in traditional Chinese medicine. Nature, flavor and meridian distribution: sweet, slightly bitter, neutral. Functions and indications: tonify vital energy, restore pulse and solidify, invigorate the spleen and lung, promote body fluid, and soothe the nerves. For physical weakness, cold limbs, slight pulse, spleen deficiency, lack of food, lung deficiency, wheezing and coughing, body fluid wound thirst, internal heat and thirst, prolonged illness and deficiency, palpitations and insomnia, impotence and cold uterus; heart failure, cardiogenic shock. [0003] Traditional Chinese medicine and integrated traditional Chine...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/7048A61K9/20A61P9/10A61P9/04A61P9/02
Inventor 孙从新王巍
Owner NAT INST OF PHARMA R & D CO LTD
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