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Filling material used for molecule brand solid phase extraction and preparation method thereof

A technology of molecular imprinting and extraction, applied in solid solvent extraction, chemical instruments and methods, chemical/physical/physicochemical processes, etc., can solve problems that are not suitable for large-scale applications, loss of column pressure at identification sites, complex preparation processes, etc. problems, to achieve the effects of small column pressure, reduced dosage, and improved separation efficiency

Inactive Publication Date: 2005-12-07
PEKING UNIV
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AI Technical Summary

Problems solved by technology

However, this preparation process is too complicated and not suitable for large-scale applications.
[0010] These two methods of using carriers also have a common disadvantage: when loaded into a separation column for use, they both rely on the molecular imprinting material itself to withstand the pressure
The molecularly imprinted polymer has a porous structure from the surface to the core, and the pressure it can withstand is not too high, especially the resistance to the contact pressure between particles (the reaction is local high pressure), and it is easy to break during use. , resulting in loss of recognition sites and increased column pressure
[0011] In addition, some people have prepared molecular imprinted films on the electrode surface (Shoji R, Takeuchi T, Kubo I, ANAL CHEM75(18): 4882-4886 SEP 15 2003), but due to its small surface area, it can only be used for trace detection

Method used

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  • Filling material used for molecule brand solid phase extraction and preparation method thereof
  • Filling material used for molecule brand solid phase extraction and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] 1. Experimental materials

[0042] 1.1 Source

[0043] Emodin was purchased from Huaian Jiutai Biochemical Co., Ltd., with a purity greater than 98%.

[0044]Acrylamide (AA), trimethylolpropane trimethacrylate (TRIM), and azobisisobutyronitrile (AIBN) were purchased from Bailingwei Chemical Reagent Company. TRIM was treated as follows before use: TRIM was washed with 10% aqueous sodium hydroxide solution, dried with anhydrous magnesium sulfate, and then redistilled under reduced pressure. AIBN was recrystallized from methanol before use.

[0045] Tetrahydrofuran (THF) is chromatographically pure, dried over sodium and redistilled before use. Methanol and acetonitrile are chromatographically pure, and acetic acid is analytically pure.

[0046] 500-mesh hollow glass microspheres, triethoxyvinylsilane and triethoxyaminoethylsilane were purchased from Qingdao Haid Chemical Reagent Company.

[0047] 0.75mm inner diameter PEEK tubes and various PEEK joints (concave and c...

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PUM

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Abstract

The invention relates to a padding used to do molecule brand solid-phase extraction and it's preparing method. The carrier of the padding is glass bead which has been surface modified. The preparing method of padding is using liquid film method to form a polymeric film layer with molecule brand at the surface of carrier.

Description

technical field [0001] The invention relates to a filler for molecular imprinting solid phase extraction, in particular to a novel carrier for molecular imprinting solid phase extraction filler and molecular imprinting polymer filler prepared by using the carrier. The present invention also relates to a method for preparing the above-mentioned filler. Background technique [0002] Molecular imprinting technology is a relatively advanced means of material separation, which is often combined with solid phase extraction to separate substances that are difficult to separate by conventional means, such as separating specific active ingredients in crude plant extracts with complex components. In 1972, Wullf et al first applied the molecular imprinting technique to the chiral separation of glucose derivatives (G.Wulff, A.Sarhan, Angew.Chem., Int.Ed.Engl., 341, 1972, 11). [0003] The most critical thing when using molecular imprinting technology for solid phase extraction is to pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02
Inventor 徐筱杰骆宏鹏庄艳陈丽蓉
Owner PEKING UNIV
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