Domperidone drip pill and its preparation method

Abstract

A dripping pill of domperidone for treating indigestion, nausea, vomiting, etc is prepared from domperidone and medicinal carrier.

Description

technical field [0001] The invention relates to a pharmaceutical composition with gastrointestinal prokinetic effect for treating dyspepsia, abdominal distension, belching, nausea and vomiting, in particular to an oral preparation of the pharmaceutical composition prepared from domperidone. Background technique [0002] Domperidone is a gastric motility and antiemetic drug developed by Janson Company in Belgium. It is used to treat functional, organic and infectious nausea, vomiting and non-ulcer dyspepsia. "Guidelines for Product Development" is a product recommended by the relevant state departments to concentrate on R&D and localization. The drug was first launched in Belgium in 1978 and has been successively launched in Germany, Italy, Britain, Japan, France and other countries, and has been widely used in countries all over the world. my country introduced this product in 1986, and Xi'an Janssen Company exclusively imported raw materials to produce preparations and sel...

AI Technical Summary

Problems solved by technology

Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect

In addition, conventional oral dosage forms, such as tablets, capsules, etc., will produce relatively large dust pollution due to the granulation process in the preparation process, which will cause harm to the health of the staff to a certain extent, and will also cause harm to the human body. some pollution to the environment

Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.