Borneol fatly acid ester derivative and preparation containing said derivative

Abstract

A derivative of the borneol ester of fatty acid, which is a target auxiliary of the medicine for treating cerebral diseases, is prepared through esterifying reaction between borneol or isoborneol and the straight-chain or branch-chani C5-C30 fatty acid.

Description

Technical field: The invention relates to the technical field of medicine, in particular discloses a derivative containing borneol and fatty acid (borneol fatty acid ester derivative) and a preparation containing the derivative. Background technique: There are two types of borneol: natural borneol and synthetic borneol. Natural borneol is a processed product of dipterocarp resin of the Brainaceae plant. Due to the shortage of resources, artificial synthetic products such as camphor and turpentine are used as raw materials (edited by Jiangsu New Medical College. "Dictionary of Traditional Chinese Medicine" Shanghai People's Publishing House, 1977 Year 951.) The structure of an ice sheet is as follows: Borneolum is pungent, bitter, slightly cold. GUIXIN, Spleen, Lung Channel. Have one's ideas straightened out refreshing, clear away heat and relieve pain. For febrile coma, convulsions, apoplexy due to phlegm, qi depression and violent syncope, middle-evil coma, conjuncti...

AI Technical Summary

Problems solved by technology

Because borneol has strong volatility, it brings difficulties to the preparation process, and at the same time, after long-term storage, the drug loss is serious, resulting in unguaranteed drug efficacy. It can be considered to connect a lipid group to the borneol molecule to prepare borneol derivative

The reported borneol derivatives are borneol glucuronide (HUEBNER CF, LINK KP. Note on the bornyl ester of bornyl d-glucuronide. J Biol Chem. 1950Sep; 186 (1): 393-4.) etc. , but no derivatives indicated in the present invention

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