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New use of ginseng saponin-Re medicine and its preparation method

A new technology of ginsenosides, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of undiscovered PD mouse protection, achieve complete impurities, good separation effect, and enrichment concentrated effect

Inactive Publication Date: 2005-08-10
辽宁光太药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the protective effect of Re on PD mice caused by MPTP has not been found.

Method used

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  • New use of ginseng saponin-Re medicine and its preparation method
  • New use of ginseng saponin-Re medicine and its preparation method
  • New use of ginseng saponin-Re medicine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 (ginseng raw material is ginseng flower bud)

[0033] A. Soaking and decocting

[0034] (A) Take 1 kg of ginseng flower buds and put them in a container, then add 16 liters of tap water to the container, soak at room temperature for 4 hours, then heat the mixture of the two to 80-90° C., keep it warm for 4 hours, and then filter the residue to take the liquid;

[0035] (B) Add 10 liters of tap water to the slag filtered out in step (A), and heat the mixture to 80-90° C., keep it warm for 3 hours, and then take the liquid from the filter slag;

[0036] (C) Add 8 liters of tap water to the slag filtered out in step (B), and heat the mixture to 80-90° C., keep it warm for 1.5 hours, and then take the liquid from the filter slag;

[0037] B Liquid Concentrate

[0038] The liquids produced by the steps (A), (B) and (C) are mixed together and then concentrated under reduced pressure until it is concentrated to about 3 liters;

[0039] C adsorption, elution

...

Embodiment 2

[0048] Embodiment 2 (ginseng raw material is ginseng leaf)

[0049] A. Soaking and decocting

[0050](A) Take 10 kg of ginseng stems and leaves and put them in a container, then add 160 liters of tap water to the container, soak at room temperature for 2 hours, then heat the mixture of the two to 95-100°C, keep it boiling for 2 hours, and then take the filter residue liquid;

[0051] (B) Add 100 liters of tap water to the slag filtered out in step (A), and heat the mixture to 95-100° C., keep it warm for 2.5 hours, and then take the liquid from the filter slag;

[0052] (C) Add 80 liters of tap water to the slag filtered out in step (B), and heat the mixture to 95-100° C., keep it warm for 1 hour, and then take the liquid from the filter slag;

[0053] B Liquid Concentrate

[0054] The liquids produced by each of the working steps (A), (B) and (C) are mixed together and then concentrated under reduced pressure until it is concentrated to about 20 liters;

[0055] C adsorpt...

Embodiment 3

[0064] Embodiment 3 (ginseng raw material is ginseng fruit)

[0065] 5. Soaking and decocting

[0066] 6. Take 10kg of fresh ginseng juice and put it into the container, then add 100 liters of tap water into the container, heat the mixture of the two to 80-90°C, keep it warm for 1 hour, and then filter the residue to get the liquid;

[0067] (B) Add 80 liters of tap water to the slag filtered out in step (A), and heat the mixture to 95-100° C., keep it warm for 1 hour, and then take the liquid from the filter slag;

[0068] (C) Add 80 liters of tap water to the slag filtered out in step (B), and heat the mixture to 95-100° C., keep it warm for 1 hour, and then take the liquid from the filter slag;

[0069] B Liquid Concentrate

[0070] The liquids produced through the steps (A), (B) and (C) are mixed together and then concentrated under reduced pressure until they are concentrated to about 20-30 liters;

[0071] C adsorption, elution

[0072] Make the concentrated liquid p...

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PUM

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Abstract

An application of the ginsenoside-Re in preventing and treating Parkinson's disease is disclosed. A process for extracting ginsenoside-Re includes immersing raw ginseng in water, dicocting, filtering to obtain liquid, concentrating, absorbing by macroreticular resin column, eluting with low-concentration alcohol, collecting the eluting liquid, recovering alcohol, and recrystallizing altermatively in alcohol-water and methanol-water.

Description

Technical field: [0001] The invention belongs to the field of medicine and health care. Background technique: [0002] Ginseng has a medicinal history of thousands of years as a nourishing treasure. It has the functions of "tonifying vitality, quenching thirst, calming the nerves and improving intelligence". Ginsenoside (-Re), hereinafter referred to as Re, is one of the active ingredients of ginseng First, its biological activity is extensive. Modern pharmacological research has confirmed that ginsenosides have a wide range of functions such as regulating endocrine, anti-oxidation, increasing substance metabolism and improving the body's immune function. Re belongs to panaxatriol type saponins, and is one of the monomers with more content in ginsenosides. [0003] Parkinson's disease (PD) is a degenerative disease of the central nervous system that often occurs in middle-aged and elderly people, and the incidence rate in developed countries is as high as 1%. With the inc...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P25/16
Inventor 徐琲琲张万琴曹颖林路金才徐绥绪宋少江张国刚裴玉萍窦德强
Owner 辽宁光太药业有限公司
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