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Composition extracted from Danzhi Xiaoyao Powder and application thereof

A technology of Danzhi Xiaoyao powder and compound, which is applied in the field of compound, can solve the problems of uncertain curative effect and poor repeatability, and achieve the effect of improving bioavailability and enhancing curative effect.

Inactive Publication Date: 2005-07-06
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] From the above, it can be seen that although the curative efficacy and clinical application range of Danzhi Xiaoyao Powder are very wide, due to the traditional decoction method and preparation process of traditional Chinese medicine, there are problems of uncertain curative effect and poor repeatability.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Mix the coarse powder of Danzhi Xiaoyao powder according to the prescription ratio, the total weight is 5000g, add petroleum ether 12000-20000ml, heat and reflux in water bath for 4 times, the reflux time is 2h, 1.5h, 1.5h and 1.5h respectively; the temperature of water bath is 70 ~90°C; combine the extracts, filter, vacuum the filtrate in a rotary evaporator, reduce the pressure, and concentrate to obtain petroleum ether extract. It is 62 g of brown viscous oil (active component 1), and the yield is 1.24%.

[0025] Take half of the medicinal dregs obtained by filtering by the above method, evaporate the petroleum ether, add water and decoct 3 times, the decoction time is 2h, 1.5h, 1.5h respectively, combine the water extracts, filter, and the filtrate is extracted in a rotary evaporator After vacuuming, depressurize, concentrate to obtain 2500ml of concentrated solution, and discard the residue. Add 95% ethanol to the concentrated solution until the alcohol content of...

Embodiment 2

[0029] Test results and their analysis

[0030] experimental report

[0031] Animals: The rats used include Wistar rats and SD rats, and the mice are Kunming mice.

[0032] Drugs: active ingredients 1 to 4

[0033] Experiment Report 1 Anxiety Test

[0034] ——Rat social contact experiment

[0035] Experimental Animals and Grouping

[0036] SD rats, 106 males, weighing 180-220 g, were raised with 2 per cage, free to eat and drink, and exposed to natural light. They were randomly divided into 9 groups: normal saline group, polysaccharide high-dose group, petroleum ether high-dose group, alcohol-extracted liquid high-dose group, water-extracted alcohol-precipitated liquid high-dose group, and the above groups were raised in separate cages without any modeling method.

[0037] Drugs and Administration Methods

[0038] Use normal saline, the original decoction and high dosage of polysaccharide, high dosage...

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PUM

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Abstract

The invention discloses a compound which is prepared from the effective compositions of the traditional Chinese medicinal prescription of Danzhi Ease Powder by a predetermined proportion, the compound has the functions of treating depression, dysphoria, sleep-disorder, sub-health state and apocamnosis.

Description

technical field [0001] The invention relates to a composite, in particular to a composite composed of active ingredients extracted from Mingfang Danzhi Xiaoyao Powder. The invention also relates to the application of the compound in the preparation of medicines for treating depression, anxiety, sleep disorder, sub-health state and fatigue syndrome. Background technique [0002] Danzhi Xiaoyao San, also known as Jiawei Xiaoyao San, was first recorded in "Internal Medicine Abstract". In terms of parts by weight, it consists of 3 parts of Zhigancao, 6 parts of Angelica, 6 parts of Paeoniae Alba, 6 parts of Poria cocos, 6 parts of fried Atractylodes macrocephala, 6 parts of Bupleurum, 3 parts of fried gardenia and 3 parts of paeonol. [0003] Danzhi Xiaoyao Powder has the following effects: Nourishing blood and soothing the liver, clearing away heat and purging fire; treating deficiency of liver and spleen blood, inflammation of asthenia fire, bone steaming and hot flashes, spo...

Claims

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Application Information

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IPC IPC(8): A61P25/20A61P25/22A61P25/24
Inventor 徐志伟严灿吴丽丽
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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