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Method for extracting and synthesizing thymus microcapsule sustained release needle by PLGA

A thymosin and sustained-release needle technology, applied in the field of thymosin drugs, can solve the problems that polypeptide drugs are difficult to pass through biological barriers, numerous steps, complicated processes, etc., so as to prolong the action time of drugs, reduce the dosage of administration, and avoid toxic and side effects. Effect

Inactive Publication Date: 2005-06-29
刘金雪
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] With the development of molecular biology and its technology, polypeptide drugs have shown better therapeutic effects than traditional drugs, but polypeptide drugs have their inherent disadvantages: 1. They are easily degraded by proteolytic enzymes in the gastrointestinal tract when taken orally, so Must be administered by injection; 2. The biological half-life is extremely short, so repeated injections are required; 3. Most peptide drugs are not easy to pass through biological barriers
The extraction method of thymosin injection produced in my country is complex, with many steps, low protein yield and low biological activity, and because thymosin preparation is an immunomodulatory drug that acts on the T cell system, the course of treatment is about 4-6 weeks, such a long treatment The process greatly limits its clinical application

Method used

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Embodiment Construction

[0008] A method for extracting and synthesizing thymosin microcapsule slow-release needles by using PLGA, which is characterized in that: it is completed by the following steps: ① first dissolving thymosin in a small amount of water to make the inner layer water phase; ② making the shell material PLGA (polyethylene Lactide) is dissolved in organic solutions such as dichloromethane and acetone to make an organic phase; ③under high-speed stirring, the inner water phase is dispersed in the organic phase to form a water-in-oil emulsion (called emulsion 1); ④ Emulsion 1 is added to the outer layer water phase containing dispersant, and stirred to form a double-layer emulsion to make water / oil / water multiple emulsion; ⑤Under stirring, the organic solvent is volatilized and the polymer layer is solidified to form a solid Microspheres, thymosin is wrapped in the center of the microspheres.

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Abstract

The invention discloses a method for extracting and synthesizing thymus microcapsule sustained release needle by PLGA which comprises the following steps, (1) carrying out thymolysis in small amount of water, obtaining inner layer water phase, (2) dissolving the PLGA into organic solution, obtaining organic phase, (3) dispersing the inner layer aqueous phase into organic phase during high-speed agitating, obtaining water-in-oil type emulsion (emulsion 1), (4) charging emulsion 1 into outer layer aqueous phase containing dispersing agent, agitating to form double layer emulsion, obtaining water / oil / water composite emulsion, (5) volatilizing the organic solvent and curing the polymeric layer, forming solid microsphere, thus coating the thymus gland at the center of the microsphere.

Description

[0001] Field: [0002] The invention belongs to thymosin drugs, in particular to a method for extracting and synthesizing thymosin microcapsule slow-release needles by using PLGA. Background technique: [0003] With the development of molecular biology and its technology, polypeptide drugs have shown better therapeutic effects than traditional drugs, but polypeptide drugs have their inherent disadvantages: 1. They are easily degraded by proteolytic enzymes in the gastrointestinal tract when taken orally, so Must be administered by injection; 2. The biological half-life is extremely short, so repeated injections are required; 3. Most peptide drugs are not easy to pass through biological barriers. These disadvantages limit their clinical applications. Thymosin is extracted from the thymus tissue of mammals and contains polypeptide immune hormones. It is an essential factor for the maturation, differentiation and functionalization of T lymphocytes in the animal immune system. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K38/21A61P1/16A61P31/12
Inventor 刘金雪
Owner 刘金雪
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