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Injectio for activating pulse and its preparing method

A technology for preparation and water for injection, applied in the field of Shengmai injection preparation and its preparation, can solve the problem of not controlling pH value and the like, and achieve the effects of controlling production cost, high safety and good pharmacological effect

Active Publication Date: 2005-06-22
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The standard of drug standard number WS3-B-2865-98 adopts the traditional ethanol extraction method of ginseng, and also adopts separate extraction methods for Ophiopogon japonicus and Schisandra chinensis, but this method does not control the pH value. Therefore, after heating Under certain conditions, a lot of 5-hydroxymethylfurfural will also be produced

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Long-term Pharmacological Experiment of 5-Hydroxymethylfurfural

[0036] The effective and effective pharmacological experiment of 5-hydroxymethylfurfural has been carried out in the patent 97107191.8. The present invention only conducts long-term pharmacological experiments on rats and observes various conditions of rats to verify the effect of 5-hydroxymethylfurfural on striated muscles and viscera. damage.

[0037] Experimental drug: 5-Hydroxymethylfurfural (provided by the laboratory of Beijing Qianluchun Technology Co., Ltd., analyzed by the Natural Medicine Laboratory of Shenyang Pharmaceutical University, and its purity is more than 95%).

[0038] normal saline

[0039] Experimental animals: 60 wistar rats, weighing (200±20) g, were randomly divided into 2 groups, 30 rats in each group, ♀♂ in half.

[0040] Experimental method: get rats, and administer daily tail vein and normal saline, once a day (5-hydroxymethylfurfural group dosage 150mg / ml, administration 1...

Embodiment 2

[0050] Protective effect on acute myocardial ischemia in rats

[0051] Experimental drug: Shengmai Injection (Jilin Province Ji'an Yisheng Pharmaceutical Co., Ltd.);

[0052] Shengmai injection preparation of the present invention (provided by the laboratory of Beijing Ganluchun Technology Co., Ltd.)

[0053] Normal saline (provided by the laboratory of Beijing Qianluchun Technology Co., Ltd.)

[0054] Experimental animals: Animals 50 Wister white rats, male, weighing (300±20) g, were divided into 5 groups, 10 in each group.

[0055] Experimental method: Ligate the left anterior descending coronary artery in rats to create an acute myocardial ischemia model. Each group was given tail vein administration (5.5g / kg administration), anesthetized with 20% urethane (1g / kg, ip), isolated the common carotid artery, paralleled tracheal intubation, and connected the animal ventilator. The left fourth intercostal space was opened, the pericardium was cut, the left anterior descending ...

Embodiment 3

[0081] (1) raw material medical material proportioning weight part of the present invention is:

[0082] 500 grams of ginseng, 1500 grams of Ophiopogon japonicus, 750 grams of schisandra;

[0083] (2) Ginseng was extracted three times with 85%, the first and second times were 3 hours respectively, and the third time was 2 hours. The extracts were combined, concentrated under reduced pressure and recovered ethanol to the utmost, and water was added until the ratio of medicinal materials was 1:1 (V / W), stand still, separate and remove the upper layer of oil, filter, concentrate the filtrate to a relative density of 1.15-1.20 at 50°C, and vacuum-dry at 70°C to obtain 20 grams of effective parts of ginseng; 1 hour, 45 minutes and 30 minutes for the second and third times respectively, combine the extracts, concentrate under reduced pressure to a relative density of 1.05-1.10 (heat measurement at 50°C), add ethanol until the alcohol content is 75%, let stand, and filter , the fil...

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Abstract

Disclosed is an injection for activating pulse and its preparing method, wherein the injection is prepared from the effective parts extracted from Chinese medicinal herbs including gen-seng, lilyturf root, schisandra chinensis. The prepared injection preparation can increase gen-seng glycosides extraction rate.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Shengmai injection preparation and a preparation method thereof. Background technique [0002] Shengmai injection is derived from the ancient prescription Shengmaisan, which is composed of ginseng, Ophiopogon japonicus and Schisandra chinensis. Jue cold, sweating, sudden pulse, myocardial infarction, cardiogenic shock, septic shock, etc. have the above syndromes. [0003] The traditional process of extracting ginseng uses 50%-70% ethanol as a solvent for extraction. Through a large number of experimental studies, we found that using high-concentration ethanol for extraction can improve the extraction rate of ginsenosides, and then use water precipitation to remove some ineffective components. , so that the effective parts of ginseng can be fully utilized. [0004] 5-Hydroxymethylfurfural is an aldehyde compound produced by the dehydra...

Claims

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Application Information

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IPC IPC(8): A61P9/00A61P9/10
Inventor 张正生
Owner TIANJIN TASLY ZHIJIAO PHARMA
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