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Freeze-dried powder and injection preparation of red sage root and safflower, and preparation method

A technology for freeze-dried powder for injection and powder for injection, which is applied in the fields of traditional Chinese medicine Danhong injection and freeze-dried powder for injection, can solve the problems of inconvenient transportation, instability, poor purification effect, etc.

Inactive Publication Date: 2005-06-15
张正生
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current ministerial standard adopts the method of extracting salvia miltiorrhiza with dilute alcohol, and extracting the dregs after alcohol extraction with safflower. The purification effect is not good, the content of active ingredients is not high, and the injection liquid injection made is unstable. It is also not easy to transport, therefore, its ideal dosage form is freeze-dried powder injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1: Specification of 10,000 bottles

[0058] (1) Take 15000g of Salvia miltiorrhiza medicinal material, crush it into coarse powder, heat and decoct it with 0.1% sodium bisulfite aqueous solution for 3 times, 60min each time, combine the extracts, centrifuge at 20000r / min, and adjust the pH of the centrifuged liquid with hydrochloric acid Value to 2, refrigerate, filter, add the filtrate to the processed D 101 On the macroporous resin column, first wash away impurities with 2 times the volume of the resin column, and then eluted with 3 times the volume of 30% ethanol, collect the 30% ethanol eluate, and recover the ethanol under reduced pressure to the liquid and crude drugs The ratio of the amount is 1:2, the extracts are extracted 4 times with ethyl acetate, the extracts are combined and the solvent is recovered under reduced pressure to dryness to obtain the total phenolic acid components of Salvia miltiorrhiza.

[0059] (2) Take 5000g of safflower, crush it by we...

Embodiment 2

[0061] Example 2: 1000 bottles of specifications

[0062] (1) Take 1500g of Salvia miltiorrhiza medicinal material, crush it into coarse powder, heat and decoct it with 0.1% sodium metabisulfite aqueous solution for 3 times, 90min each time, combine the extracts and centrifuge at high speed (10000r / min), adjust the pH value of the centrifuged liquid with hydrochloric acid To 2.4, refrigerate, filter, and add the filtrate to the processed AB-8 type macroporous resin column, first eluting with 2 times the volume of the resin column, and then eluting with 4 times the volume of 40% ethanol , Collect 40% ethanol eluate, recover under reduced pressure until the ratio of drug solution to crude drug is 1:2, extract 3 times with saturated n-butanol, and recover the solvent to dryness of the extract under reduced pressure to obtain total salvia miltiorrhiza Acidic ingredients.

[0063] (2) Take 500g of safflower, pulverize it by wet method, heat and decoct it with an aqueous solution contai...

Embodiment 3

[0065] Example 3: 5000 bottles of specifications

[0066] (1) Take 7500g of Salvia miltiorrhiza medicinal material, crush it into coarse powder, heat and decoct it with 0.1% vitamin C aqueous solution for 4 times, 60min each time, combine the extracts and centrifuge at high speed (15000r / min), and adjust the centrate with acid pH value to 2, refrigerate, filter, add the filtrate to the processed D 101 On the macroporous resin column, first elute with 2 times the volume of the resin column, discard the water eluent, and then elute with 3 times the volume of the resin column 30% ethanol, and collect the 30% ethanol eluent , Recover the solvent under reduced pressure until the ratio of the liquid to the crude drug is 1:2, extract 4 times with ethyl acetate, and return the extract to the solvent under reduced pressure to dryness to obtain the total phenolic acid components of Salvia miltiorrhiza.

[0067] (2) Take 2500g of safflower, wet pulverize and extract 5 times by heating and de...

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PUM

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Abstract

A freeze-dried powder injection is prepared from red sage root and safflower. Its preparing process features that the water-soluble antioxidant is used in hydrothermal extraction, high-speed centrifuge, macroreticular adsorption and ultrafilter by hollow fibre column are used. Its advantages are high curative effect and high quality.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and specifically relates to a traditional Chinese medicine Danhong injection composed of Danshen and safflower and a freeze-dried powder injection for injection and a preparation process thereof. Background technique [0002] Salvia miltiorrhiza is a traditional Chinese medicine. It is widely used clinically in the treatment of cardiovascular and cerebrovascular diseases. Its main active ingredients are water-soluble salvianolic acids, including salvianolic acids A~C, rosmarinic acid and its methyl esters, and salvia miltiorrhiza Chemical components such as protocatechualdehyde, protocatechuic acid, etc., have the effects of anti-platelet aggregation, anti-thrombosis, improvement of microcirculation, anti-oxidation damage, etc., so it can play a role in multiple ways to protect the myocardium and cardiovascular system effect. Domestic researches on water-soluble component...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61P9/10
Inventor 张正生
Owner 张正生
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