Method for preparing Chinese medicine composition for treating ischemic brain apoplexy
The technology of a composition and traditional Chinese medicine is applied in the field of preparation of traditional Chinese medicine compositions, can solve the problems of large dosage, poor stability of hygroscopic tablets of whole extract tablets, unclear active site groups, etc., and achieves low extraction and separation temperature and is feasible Good sex, the effect of reducing the dosage
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Embodiment 1
[0028] Embodiment 1: the preparation method of the Chinese medicine composition for the treatment of ischemic stroke
[0029] Prescription: Astragalus 8g, Angelica 8g, Scrophulariae 8g, Honeysuckle 8g, Dendrobium 8g, Licorice 8g
[0030] The preparation method steps are as follows:
[0031] (1) Take angelica and dry it, powder 20 meshes, put into the extraction kettle, 2 analysis kettles and tanks to heat or cool respectively, when the temperature of the extraction kettle reaches 40°C, the temperature of the analysis kettle I reaches 50°C, and the temperature of the analysis kettle II reaches At 35°C, open the CO 2 Gas cylinder, when the pressure of the extraction kettle reaches 20MPa, and the pressure of the analysis kettle II is 6MPa, the circulation extraction starts, and the CO 2 The flow rate is about 18kg / h, after 2 hours of extraction, the material is discharged from the analysis kettle, and the extract is collected;
[0032] (2) The medicinal dregs after the carbon ...
Embodiment 2
[0036] Example 2, Therapeutic Effect of Tongsaimai Composition on Ischemic Stroke Caused by Electrocoagulation of Middle Artery Rats
[0037] 1. Experimental purpose: To observe the therapeutic effect of Tongsaimai composition on ischemic stroke in rats caused by electrocoagulation of middle artery.
[0038] 2. Experimental materials
[0039] 2.1 Animals: SD rats, male, 250-300 g, purchased from the Animal Center of Nanjing Medical University.
[0040] 2.2 Drugs: The drugs are sealed and stored in a cool and dry place. After being prepared as a liquid, store at 4°C.
[0041] Tongsaimai composition: provided by Jiangsu Nanzhong University Pharmaceutical Co., Ltd., batch number: 20030926, each gram of extract contains 10.43 grams of crude drug, and the daily dose of crude drug is 51.84 grams;
[0042] Tongsaimai tablet extract: provided by Jiangsu Nanzhong University of Traditional Chinese Medicine Pharmaceutical Co., Ltd., batch number: 20030120, each gram of extract contains...
Embodiment 3
[0177] Example 3, the protective effect of Tongsaimai composition on middle cerebral artery embolism model rats
[0178] 1. Experimental materials
[0179] 1.1 Drugs and reagents
[0180] With embodiment 2.
[0181] 1.2 Experimental animals
[0182] Clean-grade male SD rats, weighing 240g to 310g, were provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd.
[0183] 2. Statistical methods
[0184] The experimental data were expressed as X±SD, and the measurement data was compared with the Student T test to compare the statistical differences, and the comparison between the behavior classification groups was performed with the rank ordinal value method (Ridit method).
[0185] 3. Test method
[0186] 3.1 Experimental scheme: The model was prepared by the internal carotid artery suture method. Adopting Longa's method to improve, the rats were intragastrically administered for 5 consecutive days, anesthetized with 10% chloral hydrate (350mg / kg, ip) 1h after administra...
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