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Method for preparing Chinese medicine composition for treating ischemic brain apoplexy

The technology of a composition and traditional Chinese medicine is applied in the field of preparation of traditional Chinese medicine compositions, can solve the problems of large dosage, poor stability of hygroscopic tablets of whole extract tablets, unclear active site groups, etc., and achieves low extraction and separation temperature and is feasible Good sex, the effect of reducing the dosage

Active Publication Date: 2005-05-18
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main active parts of the tablet are not clear, the dosage is too high (4 to 5 tablets at a time, 3 times a day), and the stability of the tablet is poor due to the high hygroscopicity of the whole extract tablet.

Method used

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  • Method for preparing Chinese medicine composition for treating ischemic brain apoplexy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation method of the Chinese medicine composition for the treatment of ischemic stroke

[0029] Prescription: Astragalus 8g, Angelica 8g, Scrophulariae 8g, Honeysuckle 8g, Dendrobium 8g, Licorice 8g

[0030] The preparation method steps are as follows:

[0031] (1) Take angelica and dry it, powder 20 meshes, put into the extraction kettle, 2 analysis kettles and tanks to heat or cool respectively, when the temperature of the extraction kettle reaches 40°C, the temperature of the analysis kettle I reaches 50°C, and the temperature of the analysis kettle II reaches At 35°C, open the CO 2 Gas cylinder, when the pressure of the extraction kettle reaches 20MPa, and the pressure of the analysis kettle II is 6MPa, the circulation extraction starts, and the CO 2 The flow rate is about 18kg / h, after 2 hours of extraction, the material is discharged from the analysis kettle, and the extract is collected;

[0032] (2) The medicinal dregs after the carbon ...

Embodiment 2

[0036] Example 2, Therapeutic Effect of Tongsaimai Composition on Ischemic Stroke Caused by Electrocoagulation of Middle Artery Rats

[0037] 1. Experimental purpose: To observe the therapeutic effect of Tongsaimai composition on ischemic stroke in rats caused by electrocoagulation of middle artery.

[0038] 2. Experimental materials

[0039] 2.1 Animals: SD rats, male, 250-300 g, purchased from the Animal Center of Nanjing Medical University.

[0040] 2.2 Drugs: The drugs are sealed and stored in a cool and dry place. After being prepared as a liquid, store at 4°C.

[0041] Tongsaimai composition: provided by Jiangsu Nanzhong University Pharmaceutical Co., Ltd., batch number: 20030926, each gram of extract contains 10.43 grams of crude drug, and the daily dose of crude drug is 51.84 grams;

[0042] Tongsaimai tablet extract: provided by Jiangsu Nanzhong University of Traditional Chinese Medicine Pharmaceutical Co., Ltd., batch number: 20030120, each gram of extract contains...

Embodiment 3

[0177] Example 3, the protective effect of Tongsaimai composition on middle cerebral artery embolism model rats

[0178] 1. Experimental materials

[0179] 1.1 Drugs and reagents

[0180] With embodiment 2.

[0181] 1.2 Experimental animals

[0182] Clean-grade male SD rats, weighing 240g to 310g, were provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd.

[0183] 2. Statistical methods

[0184] The experimental data were expressed as X±SD, and the measurement data was compared with the Student T test to compare the statistical differences, and the comparison between the behavior classification groups was performed with the rank ordinal value method (Ridit method).

[0185] 3. Test method

[0186] 3.1 Experimental scheme: The model was prepared by the internal carotid artery suture method. Adopting Longa's method to improve, the rats were intragastrically administered for 5 consecutive days, anesthetized with 10% chloral hydrate (350mg / kg, ip) 1h after administra...

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Abstract

The preparation process of Chinese medicine composition for treating ischemic brain apoplexy includes the following steps: supercritical CO2-water extracting angelica to obtain extractive, alcohol extract angelica dregs, astragalus root, figwort, honeysuckle, dendrobium stem and licorice to obtain alcohol extracted liquid; decompression recovering alcohol, concentration, centrifugation, water washing and precipitation to obtain supernatant, adsorption in macroporous resin column and alcohol elution to obtain elutent; decompressing the elutent, concentrating, drying and crushing to obtain extractum powder; and merging the extractive and the extractum powder to obtain the Chinese medicine composition. The present invention has the advantages of maintenance of volatile component in angelica, well enrichment of the effective components, high curative effect, etc.

Description

1. Technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine composition, in particular to a preparation method of a traditional Chinese medicine composition for treating ischemic cerebral apoplexy. 2. Background technology [0002] Cerebral stroke is a common and frequently-occurring disease. Cerebral stroke is generally divided into hemorrhagic stroke and ischemic stroke. This application relates to a Chinese medicine composition for the latter. [0003] There have been many examples in the prior art of treating ischemic cerebral apoplexy with traditional Chinese medicine. At present, oral Chinese patent medicines used in ischemic cerebral apoplexy include Tongmai Granules and Naoluotong Capsules. Tongsaimai Tablets was originally a traditional Chinese medicine prescription for the treatment of thromboangiitis obliterans. , nourishing yin and clearing heat, promoting blood circulation and removing blood stasis, dredging channel...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 蔡宝昌狄留庆陈涤平陆茵吴皓李伟李伟东李吉峰
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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