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Method for preparing polylactic porous microball

A technology of porous microspheres and polylactic acid, which is applied in the preparation of microspheres and microcapsule preparations, can solve the problems of many influencing factors, difficult control of porous structure, complex operation process and implementation process, and achieve simple operation process and implementation conditions mild effect

Inactive Publication Date: 2005-03-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The operation process and implementation process of these methods are more complicated, there are many influencing factors, and the porous structure of the microspheres is not easy to control, so the repeatability and quality of the obtained porous microspheres are not easy to guarantee.

Method used

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  • Method for preparing polylactic porous microball
  • Method for preparing polylactic porous microball
  • Method for preparing polylactic porous microball

Examples

Experimental program
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Effect test

example 1

[0019] Example 1: Dissolve 0.5g of polylactic acid in 9ml of dichloromethane, and add 1ml. n-Hexane, mix well and set aside. In a 200ml beaker, 100ml of polyvinyl alcohol aqueous solution with a weight volume concentration of 0.8% was added. Start stirring at a stirring speed of 500 rpm, and pour the polylactic acid in dichloromethane / n-hexane solution. The temperature was 25°C, and the mixture was stirred for 24 hours to completely evaporate the organic solvent. After the stirring was stopped, the microspheres were suspended on the surface of the solution, filtered, washed repeatedly with deionized water, collected and dried under vacuum at 35°C for 3 days. Yield is 98%, microsphere number-average particle diameter d=290 micron, see figure 1 ;The apparent density is 0.2891g / cm 3 , with an average internal pore diameter of 16±3 microns, see Figure 2a ~ Figure 2d .

example 2

[0020] Example 2: Dissolve 0.5g of polylactic acid in 9ml of dichloromethane, add 1ml of n-octane, mix well, and set aside. In a 200ml beaker, 100ml of polyvinyl alcohol aqueous solution with a weight volume concentration of 0.8% was added. Start stirring at a stirring speed of 300 rpm, and pour the polylactic acid in dichloromethane / n-hexane solution. The temperature was 25°C, and the mixture was stirred for 24 hours to completely evaporate the organic solvent. After the stirring was stopped, the microspheres were suspended on the surface of the solution, filtered, washed repeatedly with deionized water, collected and dried under vacuum at 35°C for 3 days. Yield is 97.7%, microsphere average particle size d=471 micron, see image 3 ;The apparent density is 0.2136g / cm 3 , with an average internal pore diameter of 24 ± 4 microns, see Figure 4a ~ Figure 4d .

example 3

[0021] Example 3: Dissolve 0.5g of polylactic acid in 8ml of dichloromethane, add 2ml of n-hexane, mix well, and set aside. In a 200ml beaker, 100ml of polyvinyl alcohol aqueous solution with a weight volume concentration of 0.8% was added. Start stirring at a stirring speed of 500 rpm, and pour the polylactic acid in dichloromethane / n-hexane solution. The temperature was 25°C, and the mixture was stirred for 24 hours to completely evaporate the organic solvent. After the stirring was stopped, the microspheres were suspended on the surface of the solution, filtered, washed repeatedly with deionized water, and dried under vacuum at 35° C. for 3 days after collection. Yield is 99%, microsphere mean diameter d=413 micron, see Figure 5 ;The apparent density is 0.1726g / cm 3 , with an average internal pore diameter of 30±5 microns, see Figure 6a ~ Figure 6d .

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Abstract

The preparation process of porous polylactic acid microball includes the following steps: dissolving polylactic acid in solvent dichloromethane and adding bad solvent via mixing; dissolving PVA in deionized water to prepare solution, and under stirring, pouring the polylactic acid solution into the PVA solution; volatilizing organic solvent, filtering and washing to obtain the porous polylactic acid microball. The said process is simple and has mild condition, and the obtained porous polylactic acid microball may be used widely in controlled medicine releasing system, micro cell carrier in cell engineering and adhered microball rack in tissue engineering.

Description

technical field [0001] The invention relates to a method for preparing polylactic acid porous microspheres. Background technique [0002] Polylactic acid has good physical and mechanical properties, non-toxicity, easy processability, biodegradability and in vivo absorbability, so it has important application value in many fields, especially as tissue engineering materials and drug delivery and controlled release. carrier. In the field of biomedical materials, polylactic acid can be prepared into internally compact rods, bone nails, sutures, drug microcarriers and microspheres, etc., or internally loose and porous scaffolds, non-woven fabrics and hollow microspheres etc. Among them, microspheres play a very important role in the field of biomedical materials due to their particularity in structure, variability in performance, and wide range of applications. For example, it can be used as a carrier for the embedding, delivery and controlled release of drugs, genes, polypept...

Claims

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Application Information

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IPC IPC(8): B01J13/02
Inventor 高长有洪奕沈家骢
Owner ZHEJIANG UNIV
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