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Nanometer ultrafine fibre film material of chitose and its preparation method

A technology of chitosan nanometer and ultrafine fiber, which is applied in the fields of medical science and prosthesis, can solve the problems of chitosan ultrafine fiber membrane research reports or invention patents, etc., and achieve large liquid absorption and preparation The effect of the simple process

Inactive Publication Date: 2005-01-26
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There are no research reports or invention patents on chitosan ultrafine fiber membranes in the existing ultrafine fiber repair membrane materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Take M η 0.6g of chitosan with a value of 200,000, 0.6g of PVA with a degree of polymerization of 1750±50 and a degree of alcoholysis of 98%, was dissolved in 10mL of 2% dilute acetic acid at room temperature under magnetic stirring respectively, and then the two were mixed to form 20 mL of clear spinning solution. Inject the spinning solution into a 50 mL syringe with a flat needle with an inner diameter of 0.8 mm, fix the syringe on a micro-syringe pump, and place a grounded metal receiving screen vertically at a distance of 10 cm from the needle. Connect the needle to a 10kV high-voltage DC power supply, set the flow rate to 0.1mL / h for electrospinning, and collect microfiber films with a diameter of less than 200nm on the receiving screen after 72 hours. The microfibers contain a small amount of shuttle-shaped beads .

Embodiment 2

[0014] Take M η 0.6g of chitosan for 650,000, take M η 0.6 g of 2.3 million PEO was dissolved in 20 mL of 2% dilute acetic acid at room temperature under magnetic stirring to obtain a transparent spinning solution. Also using a 50mL syringe with a flat needle with an inner diameter of 0.8mm, electrospinning was carried out under the conditions of a receiving distance of 20cm, a voltage of 15kV, and a solution flow rate of 0.1mL / h, and collected on the receiving screen after 72h. ~300nm microfiber membrane.

Embodiment 3

[0016] Take M η 0.8g of chitosan is 100,000, 1.2g of PVA with a degree of polymerization of 1750±50 and a degree of alcoholysis of 98% is dissolved in 25mL of 2% dilute acetic acid at room temperature under magnetic stirring, and then the two are mixed to form 50mL of clear spinning solution. Also use a 50mL syringe with a flat needle with an inner diameter of 0.8mm to conduct electrospinning under the conditions of a receiving distance of 15cm, a voltage of 15kV, and a solution flow rate of 0.1mL / h. microfiber membrane.

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Abstract

A nanometer superfine chitosan fibrous membrane material and its preparation process are disclosed. It belongs to tissue repair material technology. The film material with the diameter being 10 ª–mí½50ª–m, is made by chitosan with mass percent of 10-90% and polyvinyl alcohol or polyethylene oxide superfine fiber with diameter of 50nm -500nm The preparation process is: dissolving chitosan to acetic acid solution, adding PVA pr PEO into the solution, the mass ratio of chitosan with PVA / PEO being 10 / 90í½90 / 10, injecting the prepared 4%-8% spinning solution to the electrostatic spinning device for spinning to film material, therein, voltage being 5kVí½30kV, liquid inventory being 0.1mL / hí½0.5mL / h, receiving range being 5cmí½25cm. The advantages of the invention : large volume absorbing ability, favorable cell affinity, capable of degrading in vivo and promoting defect tissue repairing when the film material is utilized as artificial skin or artificial cartilage. In addition, the preparation process is simple.

Description

technical field [0001] The invention relates to a preparation method of a chitosan nanometer superfine fiber membrane material, which belongs to the tissue repair material technology. Background technique [0002] Chitosan is a deacetylated product of chitin, which has a chemical structure similar to glycosaminoglycan in the extracellular matrix, and can be degraded by lysozyme. It has been used in biomedical products such as artificial skin and surgical sutures. [0003] In the repair of skin and cartilage, chitosan can provide active sites combined with cells and bioactive substances, and has good biocompatibility. Most of the existing chitosan restorations are porous foam membranes with a thickness of more than 1 mm, or non-woven fabrics or fabrics composed of single fibers with a diameter of about 10 μm. It is very different, the latter is a fiber or fibril of 50nm to 500nm. [0004] Different from traditional spinning, electrospinning is a spinning process under the a...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/56A61L27/60
Inventor 袁晓燕张园园段斌黄小坡
Owner TIANJIN UNIV
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