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Compound diisopropylamine dichloroacetate powder and injection prreparations

A technology of compound diisopropylamine dichloroacetate powder and diisopropylamine dichloroacetate powder, applied in the field of medicine, can solve problems such as product quality decline and decomposition, and achieve the effects of reducing product quality, mild conditions, and safe clinical application

Inactive Publication Date: 2005-01-26
肖广常 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the formulations of compound diisopropylamine dichloroacetate on the market are tablets and injections. However, compound diisopropylamine dichloroacetate injection needs to be sterilized at high temperature during the preparation process, which is easy to cause decomposition and reduce product quality.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1 Compound diisopropylamine dichloroacetate powder injection has the following components, all in percent by weight:

[0013] Diisopropylamine dichloroacetate 6.93%

[0014] Sodium Gluconate 6.57%

[0015] Mannitol 86.50%

[0016] The preparation method is as follows:

[0017] Take 20g of diisopropylamine dichloroacetate raw material, 19g of sodium gluconate, add 1.5L of water for injection, stir to dissolve, add 250g of mannitol, stir to dissolve, add water for injection to 2L, add charcoal for needles, stir at room temperature, filter and decarbonize, fine filter. The filtrate is divided into 2ml per bottle, and freeze-dried to obtain a sterile freeze-dried product of compound diisopropylamine dichloroacetate.

Embodiment 2

[0018] Embodiment 2 Compound diisopropylamine dichloroacetate powder injection has the following components, all in percentages by weight:

[0019] Diisopropylamine dichloroacetate 51.29%

[0020] Sodium Gluconate 48.71%

[0021] The preparation method is the same as 1.

Embodiment 3

[0022] Embodiment 3 compound diisopropylamine dichloroacetate powder injection, the components are as follows, all are percentages by weight:

[0023] Diisopropylamine dichloroacetate 14.39%

[0024] Sodium Gluconate 13.67%

[0025] Lactose 71.94%

[0026] The preparation method is as follows:

[0027] Take 40g of diisopropylamine dichloroacetate raw material, 38g of sodium gluconate, add 3.0L of water for injection, stir to dissolve, add 200g of lactose, stir to dissolve, add water for injection to 4L, add charcoal for needles, stir at room temperature, filter to decarbonize, refine filter. The filtrate is spray-dried to obtain a sterile powder of compound diisopropylamine dichloroacetate. Then carry out aseptic sub-packaging according to each 40mg (calculated as diisopropylamine dichloroacetate) to obtain compound diisopropylamine dichloroacetate powder injection.

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PUM

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Abstract

The invention discloses a compound diisopropylamine dichloroacetate powder and injection preparations, which is prepared from the following components (by weight percent) disopropylamine dchloroacetate 0.125-51.29%, sodium gluconate 0.125-48.71%, excipient 0-99.75%.

Description

(1) Technical field [0001] The invention relates to a compound diisopropylamine dichloroacetate powder injection, which belongs to the technical field of medicine. (2) Background technology [0002] Hepatitis disease has a wide range of infections and a high incidence. According to statistics, there are more than 120 million patients with various liver diseases in my country, and everyone has such patients in their life circle. With the improvement of living standards, dietary structure and lifestyle have changed greatly, and the incidence of some "modern diseases" and "rich people's diseases" is getting higher and higher. Fatty liver is the most typical one. The incidence of fatty liver in Shenzhen is gradually increasing, and fatty liver has become the second major liver disease that threatens the health of citizens, second only to viral hepatitis. Professor Ye Hongjun pointed out that in Shenzhen, more than 10% of people suffer from this disease, and the detection rate o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/195A61P1/16A61P31/12
Inventor 肖广常张颖
Owner 肖广常
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