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4-hydroxylic pyridine and production process thereof

A technology of hydroxypyridine and production method, applied in directions such as organic chemistry, can solve problems such as no reports on the production method of 4-hydroxypyridine, and achieve the effects of high product quality, less three wastes, and convenient operation

Active Publication Date: 2005-01-05
江苏优普生物化学科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] There are many pyridine compounds, but there is no report about 4-hydroxypyridine and its production method

Method used

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  • 4-hydroxylic pyridine and production process thereof
  • 4-hydroxylic pyridine and production process thereof
  • 4-hydroxylic pyridine and production process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] Tetraaminopyridine and nitrite in inorganic acid, inorganic base R 2 (OH) 2 Under the conditions of existence, react to obtain 4-hydroxypyridine, and the reaction formula is:

[0019]

[0020] where R 1 for CH 3 -(Ethyl, propyl, butyl, phenyl, benzyl, CH 2 = CH-, CH 3 -CH=CH- etc.), R 2 It is a divalent metal ion Mg (or Ca, Fe, Cu, etc.).

[0021] The mol ratio of above-mentioned reaction feeding intake is: tetraaminopyridine: nitrite: inorganic acid: inorganic base=1: 1.0~1.5: 2.~4.: 2~4 (can be 1: 1: 2: 2 or 1: 1.5:3:3, 1:1.2:4:4); the reaction temperature is 0-80°C (can be 0°C, 20°C, 40°C, 60°C, 80°C). The inorganic acid adopts hydrochloric acid (or sulfuric acid).

[0022] The above nitrite R 1 ONO is obtained by reacting alcohol with nitrite and inorganic acid, the reaction formula is:

[0023] where R 3 It is a monovalent metal ion Na (K etc. can also be used), and the inorganic acid is hydrochloric acid (or sulfuric acid etc. are used). The m...

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Abstract

The invention discloses a 4-hydroxy pyridine and its producing method, including the steps: making tetra amido pyridine with nitrite on the condition that inorganic and organic acids exist, so as to obtain 4-hydroxy pyridine. It can act as an organic synthesis intermediate for medicines, pesticides, dyes, etc. The producing process is simple and convenient to operate, the reacting conditions are moderate, the three wastes are a few, the product quality is high and the yield is up to above 90%.

Description

Technical field: [0001] The invention relates to an organic synthesis intermediate of medicine, pesticide, dye and the like. Background technique: [0002] There are many pyridine compounds, but there is no report about 4-hydroxypyridine and its production method. Invention content: [0003] The object of the present invention is to provide a kind of 4-hydroxypyridine that can be used as the organic synthesis intermediate of medicine, pesticide, dyestuff etc. and production method. [0004] Technical solution of the present invention is: [0005] A kind of 4-hydroxypyridine, its feature: structural formula is: [0006] [0007] A kind of production method of 4-hydroxypyridine, it is characterized in that: comprise the following steps: [0008] Tetraaminopyridine and nitrite in inorganic acid, inorganic base R 2 (OH) 2 Under the conditions of existence, react to obtain 4-hydroxypyridine, and the reaction formula is: [0009] [0010] where R 1 for C n h 2n+2 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D213/68
Inventor 陶坤山施永兵
Owner 江苏优普生物化学科技股份有限公司
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