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Compound prepn. for lowering blood-sugar, and its use

A compound preparation and hypoglycemic technology, applied in the field of medicine, can solve the problems of other patients' long-term taking restrictions, toxicity, and patients unsuitable to take, and achieve the effect of low drug prices.

Inactive Publication Date: 2005-01-05
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of drug is toxic to organs such as liver and kidney, which limits its application range.
Patients with liver and kidney function diseases should not take it, and other patients are also restricted from taking it for a long time

Method used

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  • Compound prepn. for lowering blood-sugar, and its use
  • Compound prepn. for lowering blood-sugar, and its use
  • Compound prepn. for lowering blood-sugar, and its use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Embodiment 1: tablet (1000)

[0072] Taurine 50g

[0073] Metformin Hydrochloride 50g

[0074] Starch 260g

[0075] Appropriate amount of starch slurry (15%)

[0076] Talc powder 10g

[0077] Process: Mix taurine, metformin hydrochloride and starch, use starch slurry to make soft material, pass through 18 mesh sieve to make wet granules, ventilate and dry, add talcum powder, mix evenly, and compress into tablets.

Embodiment 2

[0078] Embodiment 2: effervescent tablet (1000)

[0079] Taurine 50g

[0080] Metformin Hydrochloride 50g

[0081] Tartaric acid 850g

[0082] Sodium bicarbonate 1100g

[0083] PEG 6000 150g

[0084] PVP S630 40g

[0085] Aspartame 50g

[0086] Orange Flavor 50g

[0087] Micronized silica gel 50g

[0088] Water-soluble coloring 1.5g

[0089] Process: Mix taurine, metformin hydrochloride and tartaric acid, use starch slurry to make soft material, pass through 18-mesh sieve to make wet granules, and ventilate and dry. In addition, sodium bicarbonate is made into granules, and the remaining auxiliary materials are added, mixed evenly, and compressed into tablets.

Embodiment 3

[0090] Embodiment 3: buccal tablet (1000 consumptions)

[0091] Taurine 50g

[0092] Metformin Hydrochloride 50g

[0093] Sorbitol 50g

[0094] Lactose 100g

[0095] Starch 1500 30g

[0096] PVP K30 5g

[0097] Aspartame 5g

[0098] Lemon essence 10g

[0099] Peppermint essence 5g

[0100] Magnesium Stearate 1.5g

[0101] Process: Produce films according to conventional methods.

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PUM

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Abstract

A hypoglycemic medicine for treating diabetes and repairing the damaged beta-pancreatic island cells contains the natural amino acid (taurine, cysteine and methionine) and the biguaride medicine (dimethyl biguaride and phenylethyl biguaride).

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular it is a new hypoglycemic compound preparation composed of natural amino acids and biguanide hypoglycemic drugs and its application. Background technique: [0002] Diabetes is a common and frequently-occurring disease that seriously threatens people's health. There are more than 30 million patients in my country, and millions of new ones will be added every year. According to statistics, the incidence rate of this disease has an increasing trend year by year. Therefore, the research and development of new drugs for the treatment of diabetes is one of the key points of the current medical field. [0003] Diabetes can be roughly divided into two types: Type I diabetes is an insulin-dependent disease; it is caused by insufficient insulin secretion, and insulin must be supplemented to maintain normal blood sugar. Type II diabetes is a non-insulin-dependent disease; the patient's insu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/195A61P3/10
Inventor 曾昭钧刘铮邓意辉
Owner SHENYANG PHARMA UNIVERSITY
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