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Compound for mula preparation for treating chronic hepatitis B virus and its preparation method

A technology for viral hepatitis and compound preparations, which can be applied to antiviral agents, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve problems such as less than ideal curative effect, and achieve high curative effect.

Active Publication Date: 2004-12-22
福建归真堂药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2. Chinese patent medicines: Yunzhi Gantai, Miaoling, Ganbifu, Polyporus polysaccharide, etc., but the curative effect is not satisfactory. ) treatment group had a total effective rate of 76.9%, and a basic cure rate of 41.3%, and the chronic liver transplantation (CPH) treatment group had a total effective rate of 81.4%, and a basic cure rate of 54.39%
Accordingly, there is no specific treatment for chronic hepatitis B at home and abroad, and the curative effect is not satisfactory. Therefore, it is urgent to develop new Chinese medicine preparations with high curative effect and no obvious toxic reactions.

Method used

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  • Compound for mula preparation for treating chronic hepatitis B virus and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1. The compound preparation for the treatment of chronic hepatitis B, the medicament made by the crude drug of following weight ratio:

[0026] The first group of medicines with weight ratio

[0027] 10 grams of Radix Pseudostellariae, 10 grams of Lycium barbarum, 10 grams of Atractylodes macrocephala, 12 grams of Poria, 16 grams of Polygonum cuspidatum, 20 grams of Scutellaria barbata, 40 grams of weeping grass, 12 grams of red peony, 10 grams of atractylodes, 20 grams of Hedyotis, 10 grams of Sophora flavescens, 5 grams of licorice

[0028] The second group of medicaments with weight ratio

[0029] 20 grams of Radix Pseudostellariae, 20 grams of Lycium barbarum, 20 grams of Atractylodes macrocephala, 20 grams of Poria, 25 grams of Polygonum cuspidatum, 30 grams of Scutellaria barbata, 60 grams of weeping grass, 20 grams of red peony, 20 grams of atractylodes, 30 grams of Hedyotis, 15 grams of Sophora flavescens, 10 grams of licorice

Embodiment 2

[0030] Embodiment 2. The preparation method of the compound preparation for the treatment of chronic hepatitis B, its preparation steps are:

[0031] ① Weigh 12 raw materials such as Radix Pseudostellariae, Lycium barbarum, and Polygonum cuspidatum according to the weight of Example 1, take Sophora flavescens, soak in 60% ethanol for 24 hours, heat and reflux for extraction three times, combine the extracts, filter, and recover the filtrate under reduced pressure Ethanol, and concentrated relative density 1.20 (50 ℃), standby (I);

[0032] ②Take fried Atractylodes macrocephala and Atractylodes atractylodes, soak in water for 1 hour, then steam distill to obtain distillate, cool to (4°C) for 24 hours, separate to obtain volatile oil, and set aside;

[0033] ③ Soak the medicinal dregs and heterophylla and other 9 herbs in water for 1 hour, decoct twice, combine the decoction, centrifuge at high speed, take the supernatant, concentrate to a relative density of 1.20 (50°C), and se...

Embodiment 3

[0037] Example 3. Effect of Gandekang Granules on Duck Hepatitis B Virus

[0038] 1. Experimental materials

[0039] 1.1 Drugs and reagents

[0040] Gandekang granule dry extract (batch number: 2000802) contains 5.5g of crude drug per g, orally, provided by Institute of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine.

[0041] Banzhou Yiganning Granules (batch number: 000321) Guangxi Banzhou Pharmaceutical Co., Ltd.

[0042] o-Phenylenediamine (CPD) (batch number: 99108) Nanjing Chemical Reagent Factory

[0043] Tween-2D (batch number: 000503) Shanghai Chemical Reagent Factory

[0044] ALT, AST, ALP (batch number: 20001011) Nanjing Jiancheng Institute of Bioengineering

[0045] Duck hepatitis B virus Provided by the Department of Pathology, Department of Animal Husbandry, Nanjing Agricultural University

[0046] Duck hepatitis B virus antigen single-double sandwich ELISA diagnostic kit provided by the Department of Pathology, Department of...

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Abstract

A Chinese medicine in the form of particles for treating chronic hepatitis B is prepared from 12 Chinese-medicinal materials including pseudostellaria root, wolfberry fruit, red peony root, liquorice root, etc through proportionally pretreating, concentrating, drying, pulverizing and granulating. Its advantage is high curative effect (93.66%).

Description

1. Technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a compound preparation for treating chronic viral hepatitis B prepared from Chinese herbal medicines and a preparation method thereof. 2. Background technology [0002] Viral hepatitis B is an infectious disease caused by hepatitis B virus, which seriously endangers human health and affects labor capacity. In recent years, the incidence of this disease has been increasing all over the world. It is 42.4-80.77%, and chronic hepatitis B is the most important and common liver disease, and the attack rate is more than 100-200 / 100,000 population. Accounting for the sixth place of disease mortality, domestic reports have 24-50% acute hepatitis B to develop into chronic hepatitis. The incidence of liver cirrhosis, liver cancer and chronic hepatitis B are in parallel relationship. According to literature reports, 80% of liver cancer evolves from chronic hepatitis B. At pr...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61P1/16A61P31/12
Inventor 周仲瑛金妙文
Owner 福建归真堂药业股份有限公司
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