Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Ultrafine fibre preparation of taxol and method and apparatus for preparing the same

A technology of microfiber and paclitaxel, which is applied in fiber treatment, medical preparations of non-active ingredients, pharmaceutical formulas, etc., and can solve problems such as susceptibility to infection and pain of patients

Inactive Publication Date: 2004-11-10
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, the incision is in the "open" state for a long time, and the patient is very painful and prone to infection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ultrafine fibre preparation of taxol and method and apparatus for preparing the same
  • Ultrafine fibre preparation of taxol and method and apparatus for preparing the same
  • Ultrafine fibre preparation of taxol and method and apparatus for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1. 0.28g polylactic acid PLA (containing D-configuration 2.8%, viscosity-average molecular weight is 91,000) is dissolved in the mixed solvent of 1.5ml chloroform and 1.5ml acetone, then adds 0.014g paclitaxel, ultrasonic vibration makes it Fully dissolve. The solution was then added to a 5 ml syringe, using a right angled flat spinneret made with an 8 gauge needle. The flow rate of the solution at the spinneret is 0.08ml / min, the applied voltage is 26,000 volts, and the distance between the two poles is 20cm.

[0026] The average diameter of the resulting drug-loaded fiber is 800nm, see figure 2 .

Embodiment 2

[0027] Example 2. Dissolve 0.15 g of L-polylactic acid PLLA (viscosity average molecular weight: 153,000) in a mixed solvent of 2 ml of chloroform and 1 ml of acetone, then add 0.015 g of paclitaxel, and ultrasonically oscillate to fully dissolve it. The solution was then added to a 5 ml syringe, using a right angled flat spinneret made with an 8 gauge needle. The flow rate of the solution at the spinneret is 0.07ml / min, the applied voltage is 25,000 volts, and the distance between the two poles is 20cm.

[0028] The average diameter of the resulting drug-loaded fibers is 1.0 μm, see image 3; For its release behavior in Tris-HCl buffer, see Figure 4.

Embodiment 3

[0029]Example 3. Dissolve 0.15 g of polylactic acid PLA (containing D-configuration 2.8%, viscosity-average molecular weight of 91,000) in a mixed solvent of 2 ml of chloroform and 1 ml of acetone, then add 0.075 g of paclitaxel, and ultrasonically vibrate to fully dissolve it . The solution was then added to a 5 ml syringe, using a right angled flat spinneret made with an 8 gauge needle. The flow rate of the solution at the spinneret is 0.1ml / min, the applied voltage is 28,000 volts, and the distance between the two poles is 20cm.

[0030] The average diameter of the obtained drug-loaded fibers was 1.3 μm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a superfine fiber formulation of Paclitaxel, its preparation process and apparatus, wherein the preparing process comprises dissolving the Paclitaxel into biologically degradable macromolecular solution, carrying out electrical spinning, forming superfine fiber nonwoven fabrics or fabric felt coated by Paclitaxel. The formulation is specially adapted for the localized treatment after tumor operation.

Description

technical field [0001] The invention relates to a biodegradable microfiber dosage form of paclitaxel. [0002] The present invention also relates to a preparation method of the above-mentioned ultrafine fiber dosage form. [0003] The invention also relates to a device for carrying out the above-mentioned preparation method. technical background [0004] Paclitaxel, whose trade name is Taxol, is the drug of choice for ovarian cancer and breast cancer, and it also has a good effect on other cancers. But like many other anticancer drugs, the solubility of paclitaxel in water is very poor. The paclitaxel injection currently used clinically is to dissolve paclitaxel in 1:1 polyoxyethylene modified castor oil (trade name Cremophor EL) and In the mixed solution of ethanol, it is diluted 5-20 times with normal saline before injection. However, Cremophor EL often causes strong side effects, such as hypersensitivity, nephrotoxicity, and neurotoxicity, which may lead to death in se...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/337A61K47/69A61P35/00D01D5/00D01F1/02
Inventor 景遐斌曾敬陈学思徐效义边新超徐秀玲
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com