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Drugs for ameliorating postcibal hyperglycaemia

A technology for postprandial hyperglycemia and postprandial blood glucose, applied to metabolic diseases, active ingredients of phosphorus compounds, drug combinations, etc., can solve problems such as no insulin secretion, unclear mode of action, and no observed effect

Inactive Publication Date: 2004-10-13
MITSUBISHI TANABE PHARMA CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no significant effect has been observed and its mode of action is unclear
Although acarbose (trade name: Baitangping, produced by Bayer Yakuhin, Ltd.) and voglibose (trade name: Beixin, produced by Takada Chemical industries, Ltd. .) Produced) can be used as an agent for improving postprandial hyperglycemia, but these drugs do not have insulin secretion effects
In addition, these drugs exhibit more common side effects such as increased flatulence and gas
In addition, compared with non-absorbable anion exchange resins such as cholebine, the above-mentioned sugar apple has four contraindications, so patients must take it with caution
[0003] On the contrary, as far as the present inventors know, in the study of the effect on the diurnal variation of blood glucose level in patients with hypercholesterolemia with type II diabetes, there has not been reported so far a drug that has a definite inhibitory effect on the rise in blood glucose level after a meal. pharmaceutically acceptable anion exchange resin

Method used

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  • Drugs for ameliorating postcibal hyperglycaemia
  • Drugs for ameliorating postcibal hyperglycaemia
  • Drugs for ameliorating postcibal hyperglycaemia

Examples

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Embodiment 1

[0038] (Objectives and methods)

[0039] Taking inpatients (adults, regardless of gender) with hypercholesterolemia and type II diabetes as research objects, the calorie intake of the inpatients is strictly controlled, and their blood lipid levels and blood sugar levels are controlled. The same case was compared before and after taking cholemide to study the effect of taking cholemide on the daily changes of blood lipid level and blood sugar level.

[0040] Diurnal changes in blood glucose levels were measured at a total of 10 time points. They are "before breakfast (8:00 hours), two hours after breakfast (10:00 hours), before lunch (12:00 hours), two hours after lunch (14:00 hours), before dinner (18:00 hours) ), two hours after dinner (20:00 hours), 0:00 hours, 3:00 hours, 6:00 hours and 8:00 hours the next morning".

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Abstract

It is mentioned to provide drugs for ameliorating postcibal hyperglycemia, drugs for inhibiting an increase in blood glucose level and pharmaceutical compositions for preventing or treating diabetics each containing a pharmaceutically acceptable anion exchange resin typified by colestimide. Thus, it becomes possible to provide drugs clearly exhibiting an effect of inhibiting an increase in postcibal blood glucose level.

Description

technical field [0001] The present invention relates to an agent for improving postprandial hyperglycemia comprising a pharmaceutically acceptable anion exchange resin. Background technique [0002] Known anion exchange resins used as cholesterol-lowering agents include colestimide (a copolymer of 2-methylimidazole and epichlorohydrin) (trade name: cholebine, produced by Mitsubishi Pharmaceutical Co., Ltd.) and cholestyramine resins. (Bristol-Myers Squibb Co.) as a representative, related to this type of anion exchange resin, there have been reports on the effect of lowering blood sugar levels after taking a period of time. However, no significant effect has been observed and its mode of action is unclear. Although acarbose (trade name: Baitangping, produced by Bayer Yakuhin, Ltd.) and voglibose (trade name: Beixin, produced by Takada Chemical industries, Ltd. .) Produced) can be used as an agent for improving postprandial hyperglycemia, but these drugs do not have insulin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/64A61K31/66A61K31/785A61K31/787A61P3/06A61P3/10
CPCA61K31/785A61K31/66A61K31/787A61K31/64A61P3/10A61P3/06A61K2300/00
Inventor 大庭建三
Owner MITSUBISHI TANABE PHARMA CORP
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