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Quickly disintegrating tablet containing cadotril

A tablet, rapid technology, applied in the direction of pill delivery, digestive system, drug combination, etc., can solve the problems of inconvenient administration, large volume, etc.

Inactive Publication Date: 2004-06-23
CHENGDU BOLING PHARMA TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Granules are bulky and inconvenient to administer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Rapidly disintegrating tablet

[0025] Tablets are prepared according to the following composition ratio.

[0026] prescription:

[0027] Racecadotril 6.00mg

[0028] Microcrystalline Cellulose 35.00mg

[0029]Mannitol 70.00mg

[0030] Crospovidone 12.00mg

[0031] Aspartame 2.00mg

[0032] Citric acid 3.00mg

[0033] Sodium bicarbonate 2.00mg

[0034] Poloxamer 6.00mg

[0035] 5% povidone aqueous solution appropriate amount

[0036] Magnesium Stearate 1.40mg

[0037] The tablet is prepared as follows.

[0038] Pass the active ingredient racecadotril and the listed excipients in the prescription through 80-mesh sieve respectively.

[0039] Mix racecadotril, microcrystalline cellulose, mannitol, crospovidone, aspartame, and poloxamer evenly.

[0040] Add 5% povidone aqueous solution to make a soft material, extrude and sieve through a 20-mesh sieve to granulate.

[0041] The wet granules were dried at a constant temperature of 60°C for 2 hours.

...

Embodiment 2

[0058] Example 2: Rapidly Disintegrating Tablets

[0059] Tablets are prepared according to the following composition ratio.

[0060] prescription:

[0061] Racecadotril 6.00mg

[0062] Microcrystalline Cellulose 35.00mg

[0063] Mannitol 70.00mg

[0064] Crospovidone 13.54mg

[0065] Aspartame 2.00mg

[0066] Citric acid 3.00mg

[0067] Sodium bicarbonate 2.00mg

[0068] Poloxamer 3.17mg

[0069] 5% povidone aqueous solution appropriate amount

[0070] Magnesium Stearate 1.40mg

[0071] Tablets are prepared according to the method of Example 1

[0072] The average disintegration time in the oral cavity is less than 0.5 minutes. The disintegration time in the disintegration instrument is less than 10 seconds.

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PUM

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Abstract

The present invention belongs to the field of pharmaceutical technology, and is one kind fast disintegrating tablet with active component cadotril. The tablet features its fast disintegrating in one minute after contacting saliva in oral cavity. It is prepared with active component cadotril as active component, disintegrating agent, stuffing, corrective, lubricant, adhesive and coloring agent and through mixing and tabletting. It has the features of fast disintegrating, convenient use and high leaching rate. The preparation has excipient mixture in 10-100 times the weight of the active component, disintegrating agent in 1-20 % of tablet weight and cosolvent in 0-20 % of tablet weight.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a rapidly disintegrating tablet containing active ingredient cardotril. More precisely, the rapidly disintegrating tablet of the present invention is a kind of oral pharmaceutical preparation for treating diarrhea that can be rapidly disintegrated within 1 minute of oral contact with saliva, does not need to be swallowed, has rapid onset of action, and is suitable for children. Background technique [0002] Orally fast-disintegrating tablet (or orally rapidly-disintegrating tablet) is a new pharmaceutical preparation that has emerged at home and abroad in the past ten years. Its main features are: (1) Easy to take. Orally rapidly disintegrating tablets can be administered without water, and can be administered only under the action of a small amount of saliva. In addition, they can be swallowed like ordinary tablets or disintegrated in water like dispersible tablets befor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61P1/12
Inventor 郝聪梅阙俐
Owner CHENGDU BOLING PHARMA TECH DEV CO LTD
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