Medicine composition

A composition and drug technology, applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of high dosage and substantial difficulty in drug administration, etc.

Active Publication Date: 2004-06-16
LION CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is not suitable from the point of view of palatability for people who have symptoms of gastric discomfort to take too much.
In addition, there is a problem that administration is substantially difficult for people who restrict sugar intake like diabetes

Method used

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  • Medicine composition

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Experimental program
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Effect test

preparation example Construction

[0096] According to the preparation method of the pharmaceutical composition of the present invention, it can be prepared easily with cheap equipment. In addition, according to the present invention, since the usage-amount of additives such as a sweetener can be reduced, the problem of increasing the size of the tablet as in the prior art can be eliminated. Moreover, dosage forms such as powders and granules are also possible.

[0097] 【Example】

[0098] The present invention is further illustrated by the following examples, but the present invention is not limited to these

[0099] Example.

Embodiment 1～9

[0101] According to the recipe shown in Table 1 below, the prescribed amount of each component in dry powder form was collected in a polyester bag and simply mixed. Comparative formulations 1-4 were simply mixed under the same conditions, and it was made into comparative examples 1-4.

[0102] One dose of these dry mixtures was administered to 10 test subjects, and 10 stages of evaluation were obtained by the test subjects. The points are averaged and used as the function evaluation result. And it judges based on the standard below this average point. Also, the ingredient that has an unpleasant taste when taken is sucralfate.

[0103] Judgment criteria: ×: poor ingestion (functional evaluation result: 1 to less than 3) △: average (functional evaluation result: 3 to less than 6) ○: good (functional evaluation result: 6 to less than 8) ◎: very good (function Evaluation result: more than 8 and less than 10)

[0104] Comparative prescription (mg) Example (mg)

[01...

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Abstract

Provided is a medicinal composition effective for solving the problem of the increase in tablet size to cause difficulty in taking caused by the use of a large amount of additives other than an active component for masking the disagreeable taste of the active component, and the problem of the use of mainly a sweetener for the masking of the disagreeable taste of the active component to cause inadequency from the view point of preference of a person of stomach discomfort to hate a medicine necessitating a high administration dose and having strong sweetness and that of the restriction for a person of diabetes, or the like, restricted to take sugars.This medicinal composition having improved administration feeling contains the active component giving discomfortable feeling when taking in combination with a stomachic herb drug. The pharmaceutical composition can reduce the use of additives such as sweetener and mask the taste of a component giving discomfortable feeling in taking.

Description

technical field [0001] The present invention relates to a pharmaceutical composition which is excellent in suppressing discomfort when a medicinal ingredient which produces discomfort such as bitterness, sourness, and astringent taste in the oral cavity when ingested is prepared, and a preparation method thereof. Furthermore, the present invention relates to a method for masking medicinal ingredients that cause discomfort such as the above-mentioned bitterness, and use of a crude drug that is excellent in the effect of suppressing the above-mentioned discomfort as a masking agent. Background technique [0002] Among the physiologically active ingredients used as pharmaceuticals, there are many ingredients that cause unpleasant sensations such as bitterness, sourness, and astringent taste in the oral cavity when taken. Various attempts have been made to alleviate or suppress such a feeling of discomfort at the time of taking. [0003] In the past, in order to reduce the bitt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K9/16A61K9/20A61K31/7024A61K36/00A61K45/00A61K47/00A61P1/04A61P1/14
CPCA61K31/00A61K36/54A61K36/61A61K2300/00
Inventor 星野和明白木广治
Owner LION CORP
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