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Pazufloxacin methane-sulfonate eye ointment and its producing process-anti-infection

A preparation technology of pazufloxacin mesylate, which is applied in the field of pharmaceutical preparations and its preparation, can solve the problems of long-term toxicity and reproductive toxicity, and achieve the effect of stable and controllable quality

Inactive Publication Date: 2004-04-28
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0086] 3. Toxicology
[0089] (2) Long-term toxicity

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0125] prescription:

[0126] Pazufloxacin mesylate 6.51g (calculated as 5g by Pazufloxacin)

[0127] Add eye ointment base to 100g

[0128] Preparation Process:

[0129] Take pazufloxacin mesylate for injection and sterilized ophthalmic ointment base, thoroughly grind them evenly, and pack them separately to obtain the product.

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PUM

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Abstract

The present invention relates to pazufloxacin methane-sulfonate eye ointment as a kind of quinolone antibiotic and its preparation process. It is eyeí»s ointment preparation prepared with pazufloxacin methane-sulfonate as active component and proper eye ointment matrix.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation process thereof, in particular to a quinolone antibiotic pazufloxacin mesylate eye ointment and a preparation process thereof. technical background [0002] Quinolones are a relatively new class of synthetic antibacterial drugs. They are different from other antibacterial drugs. They target bacterial DNA and prevent bacterial DNA from forming supercoils by preventing DNA topoisomerase II and IV from functioning. , further causing irreversible damage to chromosomes, resulting in the inability of bacterial cells to divide and reproduce. It has a selective toxic effect on bacteria. Bacteria's resistance to many antibiotics can be widely spread due to plasmid transfer, but quinolones are not easily affected by plasmid transfer resistance, so there is no cross-resistance with many antibacterial drugs. The antibacterial spectrum of quinolones is constantly broadening, from a single nar...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/5365A61P27/02
Inventor 刘孝乐刘智钱进许军彭红朱丹
Owner HONGYI SCI & TECH CO LTD NANCHANG
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