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Novel antibiotic preparation and process for preparing the same

A technology of antibiotics and preparations, which is applied in the field of new antibiotic preparations and their preparation, can solve the problems of poor therapeutic effect of infectious diseases, etc., and achieve the effects of low cost, abundant raw material resources, and simple production methods

Inactive Publication Date: 2003-10-22
迟玉森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention mainly solves the problem of poor curative effect on infectious diseases caused by bacteria resistant to broad-spectrum antibiotics such as penicillin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1, the leaves of the plant Populus tomentosa grown after 5 months are picked and washed, dried, and then pulverized. The pulverization fineness is 30 meshes. The pulverized raw materials are soaked in 20% ethanol aqueous solution. The ratio of raw materials to water is: Poplar raw material: water ratio is 1:3, extraction temperature is: 100°C, extraction time is 2 hours, after the extraction is completed, carry out coarse filtration to remove particulate impurities, then pass through a 400-mesh sieve to further remove impurities, and then carry out For step-by-step ultrafiltration, first use an ultrafiltration membrane module with a molecular weight cut-off of 100,000, and perform the first ultrafiltration on the above crude filtrate under a pressure of 5 bar to remove macromolecular impurities, and then use an ultrafiltration membrane module with a molecular weight cut-off of 10,000 Perform ultrafiltration to further remove impurities, collect the filtrate, a...

Embodiment 2

[0025] Embodiment 2, the leaves, branches and bark of the plant Populus tomentosa grown after 5 months were picked and washed and dried and then pulverized. The pulverization fineness was 10 meshes. The pulverized raw materials were soaked in 30% ethanol aqueous solution, and the raw materials were mixed with The water ratio is: poplar tomentosa raw material: water is 1:7, the leaching temperature is room temperature, and the leaching time is 12 hours. After the leaching is completed, carry out coarse filtration to remove particulate impurities, and then pass through a 400-mesh sieve to further remove Impurities, and then carry out graded ultrafiltration, first use an ultrafiltration membrane module with a molecular weight cut-off of 200,000, and under a pressure of 10bar, perform the first ultrafiltration on the above crude filtrate to remove macromolecular impurities, and then use an ultrafiltration membrane module with a molecular weight cut-off of 10,000 The ultrafiltration...

Embodiment 3

[0026] Embodiment 3, the leaves of the plant Populus tomentosa grown after 5 months are picked and washed, dried, and then pulverized. The pulverization fineness is 20 meshes. The pulverized raw materials are soaked in 95% ethanol aqueous solution, and the ratio of raw materials to water is: Poplar raw material: water ratio is 1:5, extraction temperature is: 50°C, and extraction time is 6 hours. After the extraction is completed, carry out coarse filtration to remove particulate impurities, and then pass through a 400-mesh sieve to further remove impurities, and then carry out Graded ultrafiltration, first use ultrafiltration membrane modules with a molecular weight cut-off of 150,000, and perform the first ultrafiltration on the above crude filtrate under a pressure of 8 bar to remove macromolecular impurities, and then use an ultrafiltration membrane module with a molecular weight cut-off of 10,000 Perform ultrafiltration to further remove impurities, collect the filtrate, an...

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Abstract

The present invention relates to a novel antibiotic preparation and its preparation method. It uses the plant populus tomentosa as raw material and makes it undergo the processes of pretreatment, pulverizing, extracting, sorting and ultrafiltering, vacuum concentrating, drying and obtaining finished product. The molecular weight of its effective component is 500-4000, and the water content of said antibiotic preparation is less than 5%. It is a novel antibiotic preparation for curing infected disease due to pathogenic bacteria with resistance to broad-spectrum antibiotics of penicillin, etc.

Description

(1) Technical field: [0001] The invention relates to the technical field of antibiotics, in particular to a novel antibiotic preparation for treating infectious diseases caused by bacteria resistant to broad-spectrum antibiotics such as penicillin and a preparation method thereof. (two) background technology: [0002] At present, in the treatment of infectious diseases caused by many germs, antibiotics are used, and broad-spectrum antibiotics such as penicillin are the most commonly used. Due to the large number of antibiotics, many pathogenic bacteria have drug resistance and even resistance. Drug properties, thereby reducing the therapeutic effect of broad-spectrum antibiotics such as penicillin, and directly affecting people's health. An antibiotic preparation has not been seen. (3) Contents of the invention: [0003] The object of the present invention aims to overcome the above-mentioned deficiencies in the prior art, and provide a kind of novel antibiotic preparatio...

Claims

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Application Information

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IPC IPC(8): A61P31/04
Inventor 迟玉森庄桂东张景茹
Owner 迟玉森
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