Application of scutellarin composition in preparing medicine for preventing and treating diabetes complication

A technology of breviscapine and a composition, which is applied to the application field of the breviscapine composition in the preparation of medicines for preventing and treating diabetes complications, can solve the problems of elevated blood pressure, no definite curative effect, etc., and achieves vision improvement, rapid effect, and improvement The effect of fundus blood flow velocity

Inactive Publication Date: 2003-10-22
朱邦豪
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even ACEI (Angiotensin Converting Enzyme Inhibitor) has no positive effect on diabetic nephropathy comorbidity
Although the synthetic drug aminoguanidine has a certain effect on the prevention and treatment of diabetic complications, it has not been used clinically for more than 40 years since it was discovered due to its significant side effects such as raising blood pressure.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Astragalus is extracted by water-alcohol method: take the medicinal material and add 95% ethanol to heat and reflux twice. For the first time, use 8 times the amount of crude drug weight of ethanol for reflux for 1 hour, for the second time 6 times the amount for reflux for 1 hour, filter, and discard the filtrate. Add water to decoct the dregs respectively, filter or continue to add ethanol to precipitate, filter, concentrate the filtrate, and dry in vacuum. Salvia miltiorrhiza is extracted by supercritical fluid extraction (pressure: 20Mpa, temperature: 34°C, CO 2 Flow: 5L·min -1 , extraction time: 3h). 1 part of breviscapine, 0.8 parts of astragalus extract, and 0.3 parts of salvia miltiorrhiza extract. Mix breviscapine with astragalus extract and danshen extract, dissolve with PEG4000, and make drop pills.

Embodiment 2

[0022] Using the whole plant of Eeigeron breviscapus (VantHand-Mazz) of the genus Asteraceae, according to the current conventional extraction method of breviscapus, such as extraction with 75% ethanol, the extract is evaporated to ethanol, concentrated, and the pH is adjusted with NaOH to 6.5 Dissolved, filtered, and the filtrate was washed with H 2 SO 4 Adjust the pH to 2.0, separate out breviscapine, and refine to obtain 100 grams of 4', 5, 6-trihydroxyflavone-7-O-glucuronide (breviscapine) extracted. Extract 80 grams of the extract by alcohol precipitation, add starch and dextrin according to the existing method of those skilled in the art, mix and granulate to make granules.

Embodiment 3

[0024] Get 100 grams of breviscapine, mix with 20 grams of the water-extracted and alcohol-precipitated extract of Radix Astragali extracted by the method of Example 1, and 100 grams of the extract of Salvia Miltiorrhiza extracted by the extraction method of Example 1, mix with PEG 4000 The matrix is ​​heated and dissolved, and the drop pills are prepared by a drop pill maker.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The present invention relates to Scutellarin, i.e. 4,5,6-trihydroxyflavone-7-O-glucuronic acid glucoside composition and its new application in preparation of medicine for preventing and curing diabetes complication. Said composition possesses the obvious therapeutic effect for curing diabetes nephropathy and diabetes ophthalmopathy complication.

Description

technical field [0001] The present invention relates to the application of the composition of breviscapine extract-4',5,6-trihydroxyflavone-7-O-glucuronide, namely breviscapine, in the preparation of drugs for preventing and treating diabetes complications. Background technique [0002] Erigeron breviscapus is the whole plant of Compositae, which has the effects of promoting blood circulation and removing stasis, regulating qi and relieving pain. Motherland medicine uses it to treat cerebrovascular diseases, and the curative effect is remarkable. Breviscapine is the active ingredient extracted from the breviscapine flower. It is now clinically used to treat cerebral insufficiency, cerebral thrombosis, sequelae caused by cerebral hemorrhage, and hyperviscosity. [0003] For the current treatment of diabetes, although there are many clinical drugs such as insulin that can effectively control the blood sugar level of diabetic patients, most diabetic patients die from related ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/7048A61P3/10
Inventor 朱邦豪
Owner 朱邦豪
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap