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Narcissus seed glycopeptide and its application

A technology of narcissus and glycopeptides, applied in the field of active substances, can solve the problem of undiscovered extraction of glycopeptides and the like

Inactive Publication Date: 2003-09-24
淄博顺达企业集团总公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no record of extracting glycopeptides from Narcissus

Method used

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  • Narcissus seed glycopeptide and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0252] Boil 10kg of narcissus and 1.5 times its weight of water at 100°C for 5 minutes to obtain cooked narcissus, then mix it with 2 times its weight of water to make a slurry. Enzymolysis at 90°C for 3 hours to obtain an enzymatic hydrolysis solution, and inactivation at 90°C to obtain an inactivated enzymatic hydrolysis solution. The inactivated enzyme hydrolyzate was centrifuged to remove the slag to obtain a supernatant. The supernatant was vacuum-concentrated at 60° C. to a concentrated solution with a concentration of 20-25%, centrifuged to remove residue, and the supernatant was precipitated with 95% ethanol for 12 hours, and the supernatant:ethanol=1:5 (volume ratio). Static sedimentation, the precipitate was separated, dissolved in water, the obtained aqueous solution was centrifuged to remove impurities, and the clear liquid was spray-dried at 120°C to obtain 250 grams of Narcissus glycopeptide.

[0253] Narcissus glycopeptide is brown or brownish-yellow amorphous ...

Embodiment 2

[0261] Boil 10kg of narcissus and 1.5 times its weight of water at 100°C for 5 minutes to obtain cooked narcissus, then mix it with 2 times its weight of water to make a slurry. Enzymolysis at 90°C for 4 hours to obtain an enzymatic hydrolysis solution, and inactivation at 90°C to obtain an inactivated enzymatic hydrolysis solution. The inactivated enzyme hydrolyzate was centrifuged to remove the slag to obtain a supernatant. The supernatant was vacuum-concentrated at 60° C. to a concentrated solution with a concentration of 20-25%, centrifuged to remove residue, and the supernatant was precipitated with 95% ethanol for 14 hours, and the supernatant:ethanol=1:4 (volume ratio). After static sedimentation, the precipitate was separated, dissolved in water, and the obtained aqueous solution was centrifuged to remove impurities, and the supernatant was spray-dried at 120°C to obtain 245 grams of Narcissus glycopeptide.

[0262] Narcissus glycopeptide is brown or brownish-yellow a...

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Abstract

The narvissus seed glycopeptide is the water soluble active matter extracted from narcissus seed, in which its glycoprotein content is 75-97%, said glycoprotein is a polysaccharide and peptide combined structure, its molecular weight is 2600-4200, in which polysaccharide content (by anhydrous glucose) is not less than 25.0% of total weight of the glycopeptide (by dried product weight), and the piptide content is not less than 50% of total weighto f the glycopeptide (by dried product weight). Said invented narcissus seed glycopeptide can be used for preparing antitumor medicine.

Description

technical field [0001] The invention relates to active substance narcissus glycopeptide extracted from narcissus and its application. Background technique [0002] In nature, plants, microorganisms, and animals all contain polysaccharides, which can exist not only in free form, but also in the form of protein combination. Sugar is combined with protein to form glycoprotein, which is the structural substance of some tissues and organs. At present, the common ones are achyranthes glycopeptide extracted from Achyranthes knuckle, heparin extracted from pig's small intestine, and chondroitin sulfate extracted from pig nose and throat cartilage. Lycium barbarum glycopeptide extracted from Lycium barbarum is also recorded in the patent literature. Due to the different sources of raw materials, the biological activities of the extracts are also different. Restricted by different sources of raw materials, there is no uniform and standardized extractio...

Claims

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Application Information

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IPC IPC(8): A61K38/16A61P35/00C07K14/415C08H1/00
Inventor 王淦宋淑玉宋波杜晓敏
Owner 淄博顺达企业集团总公司
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