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Use of potassium dehydroandrographolide succinate in preparing external used medicine

A technology for external use of drugs, Chuanhuning, applied in the directions of antiviral agent, aerosol delivery, etc., can solve problems such as changing the mode of administration, and achieve the effects of expanding the medicinal field, convenient and safe medication, and simple preparation process.

Inactive Publication Date: 2003-08-06
SICHUAN YIBIN WULIANGYE GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] C 28 h 35 KO 10 As an antiviral chemical drug, Chuanhuning is commonly used in the form of powder injections and injections. There are many restrictions and inconveniences in use. Therefore, it is necessary to change the way of administration. However, the application of Chuanhuning in the preparation of external medicines has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Take Chuanhuning: 100g

[0080] Moisturizer: Propylene Glycol, Glycerin or a mixture of both 2000ml

[0081] Preservative: Benzyl Alcohol 80ml Co-solvent: Sodium Salicylate 20g

[0082] PH regulator: Disodium hydrogen phosphate 15g Sodium dihydrogen phosphate 25g

[0083] Antioxidant: L-cysteine ​​salt 5g

[0084] Surfactant: Sodium Lauryl Sulfate 500g

[0085] Stabilizer: 1700ml of 75% ethanol Metal complexing agent: 10g of ethylenediaminetetraacetic acid prepared into 1000 sprays with a specification of 15ml / bottle.

Embodiment 2

[0087] Take Chuanhuning: 750g Moisturizer: Glycerin 3000ml

[0088] Preservative: phenylethyl alcohol 100ml Co-solvent: sodium carbonate 65g

[0089] PH regulator: citric acid 75g sodium citrate 50g

[0090] Antioxidant: L-cysteine ​​5g

[0091] Surfactant: sodium tetradecyl sulfate 600g

[0092] Stabilizer: 80% ethanol 4000ml

[0093] Metal complexing agent: 16 g of calcium disodium ethylenediamine tetraacetate was prepared into 1000 sticks of ointment with a specification of 15 ml per stick.

Embodiment 3

[0095] Take Chuan Hu Ning: 1200g Moisturizer: Polyethylene Glycol 4000 7800g

[0096] Preservative: Ethylparaben 100g

[0097] Co-solvent: sodium bicarbonate 100g

[0098] PH regulator: Dipotassium hydrogen phosphate 125g Potassium dihydrogen phosphate 85g

[0099] Antioxidant: Thiourea 15g

[0100] Surfactant: 850g diethylene glycol monolaurate

[0101] Stabilizer: 95% ethanol 3000ml

[0102] Metal complexing agent: 20 g of ethylenediamine tetraacetic acid disodium salt is prepared into 1000 bottles of lotion with a specification of 20 ml / bottle.

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Abstract

The present invention relates to an application of chuanhuning (potassium dehydroandrographolide succinate) in preparation of medicine for external application. Said invented medicine for external application is a chuanhuning spray made of chuanhuning and adding pharmaceutically-aceptable auxiliary material through a certain preparation process for curing herpes effectively and quickly.

Description

technical field [0001] The present invention relates to the application of Chuanhuning, in particular to the application of Chuanhuning in the preparation of external medicine. Background technique [0002] Chuanhuning is Potassium Dehydro-andrographolide Succinate, which is a synthetic drug prepared by reacting andrographolide with succinic anhydride. Its general chemical formula is as follows: [0003] C 28 h 35 KO 10 As an antiviral chemical drug, Chuanhuning is commonly used in the form of powder injections and injections. There are many restrictions and inconveniences in use. Therefore, it is necessary to change the way of administration. However, the application of Chuanhuning in the preparation of external medicines has not been reported. Contents of the invention [0004] The purpose of the present invention is to provide the application of Chuanhuning in the preparation of external medicine. [0005] The technical solution adopted by the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/365A61P31/22
Inventor 丁志勇苏小斌张华石兆勇张涛詹成武王正发
Owner SICHUAN YIBIN WULIANGYE GROUP
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