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Crataegus leaves flavone tablets and their preparing method

A technology of total flavonoids and hawthorn leaves, which is applied in the field of medicine, can solve the problems of slow absorption affecting curative effect, etc., and achieve the effect of facilitating drug onset, fast drug onset, and fast onset time

Inactive Publication Date: 2003-06-18
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the types of hawthorn leaf preparations are relatively traditional, such as Yixindone Tablets, Xinan Capsules, Fuxin Tablets, etc. There are various problems in traditional dosage forms, such as slow absorption, which affects the efficacy, while coronary heart disease and angina pectoris are clinical emergencies, and drugs are needed for rapid onset. first aid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The weight ratio of each component of Hawthorn Leaf Total Flavonoids Dropping Pill is:

[0016] Hawthorn Leaf Total Flavonoids 6.40g

[0017] Polyethylene glycol (6000) 24.02g

[0018] Poloxamer (188) 6.00g

[0019] The steps of preparing the total flavonoids of hawthorn leaves dropping pills are as follows:

[0020] Put 24.02g polyethylene glycol (6000) and 6.00g poloxamer (188) in a beaker, heat on a water bath at 95°C to melt, stir well, add 6.40g total flavonoids of hawthorn leaves, stir well, add 10ml medicinal Anhydrous ethanol, fully stirred to dissolve the total flavonoids of hawthorn leaves, continue to stir to volatilize the ethanol, keep warm for later use; preheat the dropping pill machine, keep the temperature of the liquid storage room at 95°C ± 2°C, and use soybean oil as the coolant. Pre-cool to 10-12°C, adjust the distance between the drip nozzle and the cooling liquid surface, pour the liquid medicine into the liquid stora...

Embodiment 2

[0023] The weight ratio of each component of Hawthorn Leaf Total Flavonoids Dropping Pill is:

[0024] Hawthorn Leaf Total Flavonoids 4.60g

[0025] Polyethylene glycol (1500) 23.00g

[0026] Poloxamer (188) 2.50g

[0027] The embodiment that prepares Hawthorn Leaf Total Flavonoids Dropping Pill method is as follows:

[0028] Put 23.00g polyethylene glycol (1500) and 2.50g poloxamer (188) in a beaker, heat on a water bath at 90°C to melt, stir well, add 4.60g total flavonoids of hawthorn leaves, stir well, add 9ml medicinal Anhydrous ethanol, stir fully to dissolve the total flavonoids of hawthorn leaves, continue to stir to volatilize the ethanol, keep warm for later use; preheat the dropping pill machine, keep the temperature of the liquid storage room at 90°C ± 2°C, and pre-cool the coolant to 10°C -12°C, adjust the distance between the drip nozzle and the cooling liquid surface, pour the liquid medicine into the liquid storage chamber, start the val...

Embodiment 3

[0031] The weight ratio of each component of Hawthorn Leaf Total Flavonoids Dropping Pill is:

[0032] Hawthorn Leaf Total Flavonoids 7.00g

[0033] Polyethylene glycol (4000) 17.50g

[0034] Poloxamer (188) 10.50g

[0035] The steps of preparing the total flavonoids of hawthorn leaves dropping pills are as follows:

[0036] Put 17.50g polyethylene glycol (4000) and 10.50g poloxamer (188) in a beaker, heat on a water bath at 98°C to melt, stir well, add 7.00g total flavonoids of hawthorn leaves, stir well, add 12ml medicinal Anhydrous ethanol, stir fully to dissolve the total flavonoids of hawthorn leaves, continue stirring to volatilize the ethanol, keep warm for later use; preheat the dropping pill machine, keep the temperature of the liquid storage room at 98°C ± 2°C, and pre-cool the coolant to 10°C ~12°C, adjust the distance between the drip nozzle and the cooling liquid surface, pour the liquid medicine into the liquid storage chamber, start the valv...

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Abstract

A dropping pill o f the common haw-leaf flavone is prepared from common haw-leaf flavone, polyethanediol and poloxamer. Its advantages are quickly curative effect and high biological utilization rate.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to an oral solid preparation mainly composed of total flavonoids of hawthorn leaves and a preparation method thereof, in particular to a total flavonoids of hawthorn leaves dropping pill preparation and a preparation method thereof. Background technique [0002] The traditional Chinese medicine hawthorn is a commonly used traditional Chinese medicine. It has the effects of eliminating accumulation and stagnation, nourishing the spleen and strengthening the stomach, and promoting blood circulation and removing blood stasis. Its chemical composition can be divided into organic acids and flavonoids. The research concluded that the main component of hawthorn promoting blood circulation and removing blood stasis is total flavonoids, and the content of total flavonoids in hawthorn leaves is relatively high. The total flavonoids of hawthorn leaves have been verified by a larg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P9/10
Inventor 苏娟张卫东吴伟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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