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Stem cell reinforcing material

A technology of enhancing materials and stem cells, applied in the direction of unknown raw materials, extracellular fluid diseases, biochemical equipment and methods, etc., can solve problems such as side effects, unclear mechanism of action, toxicity, etc., and achieve the goal of maintaining health and preventing various diseases Effect

Inactive Publication Date: 2002-12-04
NICHIMO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanism of action of SERMs is not very clear, and there are side effects such as toxicity. It is hoped that SERMs will have effective functions for humans.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0133] In this example, in order to confirm the enhancement of bone marrow hematopoietic stem cell function, experiments were carried out. Rats were irradiated with radiation and bone marrow transplanted, and measured by the mouse spleen colony method.

[0134] experiment method

[0135] 1. Breed female rats (female ICR) (8 weeks old) with the same body weight in healthy regions

[0136] 2. Prepare the rat's administration, common food, the concentrated material of isoflavone aglycone relative to the common food, and beans as the raw material of the soybean fermentation culture of Aspergillus koji. In the hydrolysis step, a mixed bait of a growth-promoting product in which Aspergillus and lactic acid bacteria coexist and coexist is obtained.

[0137] 3. Five rats in comparison area 1 and 2 and test area 1 and 2 respectively, as shown in Table 5, comparison area 1 and 2 were administered with common food, and test area 1 was administered with isoflavone glycosides added to ord...

Embodiment 2

[0159] In this example, in order to confirm that the male test substance enhances the function of bone marrow hematopoietic stem cells, the function of enhancing the stem cells of germ cells is dependent on the dosage of isoflavone aglycone, and conducts experiments. Rats are irradiated with radiation and bone marrow Transplantation was determined by mouse spleen colony method.

[0160] experiment method

[0161] 1. Breed healthy sample male rats (male ICR) (6 weeks old) with the same body weight in each area. 10 rats were bred in comparative areas 3, 4 and 5 and experimental area 4, and 5 rats were bred in experimental area 3.

[0162] 2. Prepare rats for administration, with common food, concentrated raw materials of isoflavone aglycones such as common food, or selected estrogen receptor modulators (SERMs), that is, mixed inducers with lower toxicity than tamoxifen Mixed bait made from toremifen.

[0163] 3. As shown in table 6, comparative area 3 and 4 each throw common ...

Embodiment 3

[0183] In this example, in order to confirm the dependence of enhancing the function of bone marrow hematopoietic stem cells, enhancing the function of germ cell stem cells, and the dose of isoflavone aglycone in male donors, a radiation exposure test was performed on male rats.

[0184] experiment method

[0185] 1. Breed healthy test male rats (male ICR) (6 weeks old) with the same body weight in each area. 10 rats were bred in comparison areas 6 and 7 and test areas 5 and 6, respectively.

[0186] 2. The administration of rats, prepared common food, the mixed bait of this common food and isoflavone aglycone concentrate.

[0187] 3. As shown in table 7, comparison area 6 and 7 throws common food, test area 5 throws the common food that adds the concentrated raw material of the isoflavone aglycon relative to body weight by 30 mg / kg, test area 6 throws The common food which added the concentrated raw material of isoflavone aglycone at a ratio of 100 mg / kg to the body weight ...

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Abstract

The present invention relates to an obesity-suppressing material, which can be ingested orally or absorbed in vivo, and can enhance somatic stem cells, especially bone marrow hematopoietic stem cells or stem cells that form embryonic stem cells. The stem cell enhancing material for enhancing stem cells provided by the present invention contains isoflavone aglycone which has an estrogenic action that does not inhibit the enzymatic activity of enzymes that function in cell proliferation. The stem cell enhancement material of the present invention has never existed before. The basic feature of the present invention is that because it contains isoflavone aglycone that enhances the effect of stem cells, the above-mentioned stem cell enhancing material with excellent effect is obtained.

Description

technical field [0001] The invention relates to a stem cell enhancement material capable of enhancing the function of human stem cells and animal stem cells. Background technique [0002] Stem cells are generally divided into two types: embryogenic stem cells (ES cells) and somatic stem cells. The embryogenic stem cells are stem cells that can differentiate to form all cells in the animal body and have special properties. The somatic stem cells exist in Stem cells that form the organs and roots of various organs or tissues in animals. Such somatic stem cells are known to include hematopoietic stem cells, neural stem cells, bone marrow stem cells, liver stem cells, and kidney stem cells. [0003] Hematopoietic stem cells, a type of somatic stem cells, are blood stem cells and are the most important substance in maintaining hematopoietic function. This hematopoiesis is carried out by the bone marrow. In addition, during the viviparous period, the organ that performs hematopo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P15/00A61P43/00C07D311/36C12N5/08
CPCA61P7/00A61P15/00A61P35/00A61P43/00C07D311/36A61K31/352
Inventor 武部实潘伟军
Owner NICHIMO
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