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Chinese medicine injection for stopping cancer pain

A cancer pain and injection technology, applied in the field of traditional Chinese medicine injections, can solve the problems of limited clinical application, patients with cancer pain not being well treated, etc.

Inactive Publication Date: 2002-10-02
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the abuse and dependence of this type of drug have increased significantly, and the resulting serious social problems have become increasingly prominent, which has severely restricted the clinical application of this type of drug, resulting in many cancer pain patients who have not yet received treatment. Good treatment, management of cancer pain remains a thorny issue for doctors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Get 4000g of celandine, cut it into 2cm sections, add 10 times the amount of 90% ethanol, heat and reflux for extraction three times, each time for 2 hours, combine the alcohol extracts, reclaim the ethanol under reduced pressure and concentrate to a relative density of 1.15 (50°C ), adjusted the pH value to 3.0 with 2mol / L phosphoric acid solution, refrigerated at 5°C for 24 hours, filtered, adjusted the pH value of the filtrate to 11.0 with 30% sodium hydroxide solution, extracted 6 times with an equal amount of chloroform, combined the chloroform solution, Recover chloroform, dry the residue in vacuum to obtain total alkaloid extract, then add 800ml of water for injection, stir to disperse, adjust the pH value to 5.0 with 2mol / L phosphoric acid solution, filter, add Tween-80 10ml, benzyl alcohol to the filtrate 10ml, 3.45g of sodium chloride, mix well, filter with a 0.45 μm microporous membrane, add water for injection to 1000ml, potting, and sterilizing to obtain the...

Embodiment 2

[0011] Get 2000g of celandine, cut it into 3cm sections, add 8 times the amount of 70% ethanol, heat and reflux for extraction three times, each time for 2 hours, combine the alcohol extracts, recover ethanol under reduced pressure and concentrate to a relative density of 1.07 (50°C ), adjusted the pH value to 3.5 with 1mol / L phosphoric acid solution, refrigerated at 10°C for 48 hours, filtered, adjusted the pH value of the filtrate to 10.0 with 40% sodium hydroxide solution, extracted 8 times with an equal amount of chloroform, combined the chloroform solution, Recover chloroform, dry the residue in vacuum to obtain the total alkaloid extract, then add 800ml of water for injection, stir to disperse, adjust the pH value to 3.0 with 1mol / L phosphoric acid solution, filter, add Tween-80 11ml, benzyl alcohol to the filtrate 9ml, sodium chloride 5g, mix well, filter with 0.45 μm microporous membrane, add water for injection to 1000ml, potting, sterilizing, obtains the Chinese medic...

Embodiment 3

[0013] Get 3000g of celandine, cut it into 1cm segments, add 6 times the amount of 85% ethanol, heat and reflux for extraction twice, each time for 2 hours, combine the alcohol extracts, reclaim the ethanol under reduced pressure and concentrate to a relative density of 1.10 (50 ℃), adjust the pH value to 2.0 with 1mol / L phosphoric acid solution, refrigerate at 10°C for 24 hours, filter, adjust the pH value of the filtrate to 10.5 with 20% sodium hydroxide solution, extract 4 times with an equal amount of chloroform, and combine the chloroform solution , reclaim chloroform, and vacuum-dry the residue to obtain the total alkaloid extract, then add 800ml of water for injection, stir to dissolve, adjust the pH value to 4.0 with 1mol / L phosphoric acid solution, filter, add Tween-80 10ml to the filtrate, benzene Methanol 10ml, sodium chloride 3.45g, mix well, filter with 0.45 μm microporous membrane, add water for injection to 1000ml, potting, sterilize, obtain the Chinese medicine ...

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PUM

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Abstract

The preparation method of the Chinese medicine injection using celandine as raw material for relieving pain due to cancers includes the following steps: cutting celandine, adding ethyl alcohol, heating-refluxing to make extraction, combining alcohol extract, pressure-reducing and recovering ethyl alcohol and making concentration, using phosphoric acid solution to regulate its pH value to acidity,cold-storing and filtering, using sodium hydroxide solution to regulate pH value of the obtained filtrate to basicity, using isometric trichloromethane to make extraction, combining trichloromethane solution, recovering trichloromethane, vacuum-drying residuum to obtain total alkaloid extract, then adding injection water, stirring and dissolving, using phosphoric acid solution to regulate pH value to acidity, filtering, adidng Tween-80, benzil alcohol and sodium chloride in filtrate, mixing and filtering.

Description

Technical field [0001] The invention relates to a medicine for analgesic pain caused by cancer, in particular to a traditional Chinese medicine injection. Background technique [0002] Cancer pain is a common worldwide problem. Effective analgesic treatment, especially for advanced cancer patients, is one of the four priorities of the World Health Organization's Comprehensive Cancer Programme. According to the statistics of the World Health Organization, there are about 7 million new cancer patients in the world every year, and more than 4.3 million deaths, of which 30 to 50% of the patients are accompanied by different degrees of pain when they die. The mechanism of cancer pain in modern medicine has not been fully clarified. [0003] Currently, cancer pain is still a difficult disease to conquer. The World Health Organization recommends a three-step therapy for the treatment of cancer pain. For mild pain, use non-opioid analgesics, such as: paracetamol, aspirin, ibupro...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61P29/00A61P35/00
Inventor 张平
Owner 张平
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