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Composition and formulations and their use as nociceptic, anti-anxiolytic and anabolic agents

A composition and preparation technology, applied in the field of composition and preparation, can solve the problems of unsuitable treatment, short half-life of glycosides, short half-life, etc.

Inactive Publication Date: 2002-06-19
EAST CAROLINA UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite its many applications, adenosine has a particularly short half-life (approximately 1 second)
Adenosine has a short half-life and tends to cause cramping, making it unsuitable for treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 and 2

[0040] Neoadult male Fischer 344 rats (120 g) were administered once daily carboxymethanol containing dehydroepiandrosterone (DHEA) (300 mg / kg) or methyltestosterone (50 mg / kg) by gavage. Base cellulose for a total of 14 days. Folinic acid (50 mg / kg) was administered intraperitoneally once daily for 14 days. On day 15, the animals were killed by applying microwave pulses (1.33 kW, 2450 MHz, 6.5 s) to the cranium, which immediately denatures brain proteins and prevents further metabolism of adenosine. The heart was removed from the animal and killed by snap freezing in liquid nitrogen for 10 s. The liver and lungs were removed intact and snap frozen for 30 seconds to death. Brain tissue was subsequently dissected. Tissue adenosine was extracted, converted into 1,N6-vinylidene adenosine, and analyzed by high performance liquid chromatography with a fluorescence detector according to the method of Clark and Dar (J. Of Neuroscience Methods 25:243 (1998)). The test results are ...

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PUM

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Abstract

Composition and formulations comprises a first agent such as folinic acid, pharmaceutically acceptable salts thereof or mixtures thereof, and a second agent(s)such as analgesics, muscle relaxants, mood disorder agents, anti-inflammatories, anti-migraine agents, anti-emetics, diuretics, high protein composites, and the like. The products are suitable as nociceptics and for the treatment of wasting disorders, bulimia, anorexia nervosa, anxiety, irritability and other symptoms associated with Pre Menstrual Syndrome, as well as for administration either in conjunction with steroids or to compensate adenosine depletion and / or bizarre behavior or aggression common in steroid users.

Description

technical field [0001] The present invention relates to a composition and preparation, which contains folinic acid, corresponding pharmaceutically acceptable salts or corresponding mixtures, and other agents, such as analgesics, anti-inflammatory drugs, muscle relaxants, anti-migraine agents, anti-emetic agents , and diuretics, etc. The products are suitable for use as nociceptors, for the treatment of wasting disorders associated with premenstrual syndrome, anxiety, irritability, or administered with steroids, or to compensate for the depletion of adenosine, which is common in steroid users. technical background [0002] Folinic acid is an intermediate product of folic acid metabolism and is considered to be the active form of folic acid after conversion in the body. Ascorbic acid or vitamin C is known to be necessary for the conversion of folic acid to folinic acid. Folinic acid has been used therapeutically as an antidote to folate antagonists, which block the conversio...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K9/08A61K9/10A61K9/12A23L1/30A61K9/14A61K9/20A61K9/48A61K31/167A61K31/192A61K31/519A61K31/60A61K45/00A61K45/06A61K47/06A61K47/10A61K47/26A61K47/34A61K47/42A61K47/46A61P1/04A61P1/08A61P1/10A61P3/02A61P3/10A61P9/00A61P9/06A61P9/10A61P11/00A61P15/00A61P15/16A61P15/18A61P17/02A61P17/12A61P17/14A61P19/02A61P21/02A61P25/04A61P25/18A61P25/20A61P25/22A61P25/24A61P29/00A61P31/04A61P31/12A61P35/00A61P35/04A61P37/00A61P43/00C07D475/04
CPCA61K45/06A61P1/04A61P1/08A61P1/10A61P11/00A61P15/00A61P15/16A61P15/18A61P17/02A61P17/12A61P17/14A61P19/02A61P21/02A61P25/00A61P25/04A61P25/18A61P25/20A61P25/22A61P25/24A61P29/00A61P3/02A61P3/04A61P31/04A61P31/12A61P35/00A61P35/04A61P37/00A61P43/00A61P9/00A61P9/06A61P9/10A61P3/10A61K31/525
Inventor 乔纳森·W·尼斯
Owner EAST CAROLINA UNIVERISTY
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