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Extraction and purification process of general rhubarb anthraquinone and its application in preparing kidney hypofuction-treating medicine

A technology of rhubarb total anthraquinone and its extraction method, which is applied in the field of preparation of drugs for treating renal failure, can solve problems such as unsatisfactory renal failure and environmental pollution, and achieve the effects of no environmental pollution, obvious curative effect, and low cost

Inactive Publication Date: 2002-05-22
NANJING ZHONGSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The first technical problem to be solved by the present invention is the problem of environmental pollution caused by the existing technology for extracting total anthraquinone from rhubarb, and the second problem to be solved is the unsatisfactory problem of existing conventional treatment methods and drugs for treating renal failure, so as to provide people with a non-toxic Extraction method of polluted total anthraquinones of rhubarb, and medicine for treating renal failure with total anthraquinones of rhubarb as main components

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] Take 100 kg of rhubarb decoction pieces, add 70% ethanol whose weight is 4 times that of rhubarb decoction pieces, reflux extraction 3 times, each time for 1 hour, combine the three extracts and filter, and decompress the filtrate to recover ethanol to obtain extract. After mixing the extract and the macroporous adsorbent resin, the macroporous adsorbent resin washes the column with 20% ethanol that is about 16 times the weight of rhubarb decoction pieces, discards the rinse solution and continues to elute with 75% ethanol with a pH value of 9. Recover ethanol by dehydration until there is no alcohol, adjust the pH value to 1, then filter the eluate, precipitate, and dry to obtain total anthraquinone grams of rhubarb in the form of brown yellow powder.

Embodiment 2

[0116] The dosage and process steps of rhubarb decoction pieces are the same as in Example 1, except that: 6 times of 80% ethanol is used for reflux extraction; after mixing the extract and macroporous adsorbent resin, the rhubarb is about 12 times the weight. Rinse the column with 30% ethanol of the decoction pieces; discard the washing solution and elute with 85% ethanol with a pH value of 8. After recovering the ethanol from the eluate until it has no alcohol smell, adjust its pH value to 3.

Embodiment 3

[0118] The dosage and process steps of rhubarb decoction pieces are the same as in Example 1, except that the 90% ethanol used for reflux extraction is 8 times, and after mixing the extract and macroporous adsorption resin, the rhubarb is about 8 times the weight. Wash the column with 40% ethanol of the decoction pieces, discard the washing solution, and elute with 75% ethanol with a pH value of 7. After recovering the ethanol from the eluate until it has no alcohol smell, adjust its pH value to 5.

[0119] The relevant specific data of above-mentioned three embodiments are as follows:

[0120] Batch Amount of Medicinal Material (kg) Amount of Dry Paste (kg) Purity (%) Determination of Content (Emodin + Chrysophanol)

[0121] (mg / g)

[0122] 001 100 3.04 54.5 321.6

[0123] 002 100 2.92 56.0 341.6

[0124] 003 100 3.01 54.3 350.0

[0125] The medicine that is used to treat renal failure with total anthraquinones ...

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PUM

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Abstract

The extraction method of rhubarb total anthraquinous includes the following steps: (1). mixing rhubarb pieces and concentrated ethyl alcohol according to weight ratio of 1:4-8, extracting for 3 timesby using reflux process; (2). filtering extraction liquor, recovering ethyl alcohol and making the filtrate into extract; (3) adding the extract to macropore adsorption resin column, using dilute ethyl alcohol to flush, then removing flushing liquor and continuously using concentrated ethyl alcohol to flush; (4). taking out eluant and recovering ethyl alcohol, and regualting pH value of eluant toacidity,; (5). filtering eluant and drying solid matter obtained by preciptation to obtain the invented product. Said product can be used preparing medicine for curing renal failure, in which the rhubarb total anthraquinone content must be above 50%.

Description

technical field [0001] The invention relates to a method for extracting total anthraquinones from rhubarb and its application in preparing medicines for treating renal failure. Background technique [0002] Chronic renal failure is a worldwide problem, and there are millions of patients in my country alone, which seriously affects the improvement of people's health and quality of life. At present, the diet is controlled clinically, patients cannot persist for a long time, and the curative effect of oral angiotensin-converting enzyme inhibitors is uncertain. Therefore, many patients are willing to undergo hemodialysis and kidney transplantation. However, due to the need for special equipment, insufficient kidney sources and high costs, only Few are able to take this treatment. [0003] Rhubarb is a commonly used traditional Chinese medicine, which has a more obvious effect on preventing chronic kidney disease from developing into uremia. According to the appli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P13/12C07C46/10C07C50/18C07C51/48C07C65/40
Inventor 王志华汤为陈妍郭莉王启慧何明芳郭应球
Owner NANJING ZHONGSHAN PHARM CO LTD
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