Medicine for treating cerebral infarction, coronary heart disease and angina pectoris

A technology for coronary heart disease, angina pectoris, and cerebral infarction, applied in the field of plant materials, can solve problems such as unsatisfactory quality control, general curative effect, and use restrictions

Inactive Publication Date: 2007-05-23
马耀茹
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the western medicines used clinically to treat cerebral infarction mainly include: urokinase, streptokinase, tissue plasminogen activator and recombinant tissue plasminogen activator, defibrase, heparin and warfarin, low molecular weight heparin , clinical use found that they all have certain limitations, the onset of effect is also slow, and the curative effect is not significant enough; the oral preparations of Chinese patent medicines mainly include Huatuo Zaizao Pills, Tongpuluji, Naoan Capsules, etc. There are many varieties, and their efficacy The effect is slow, and often does not adapt to the development of the disease course. Injections include Danshen injection, puerarin injection, safflower injection, compound Danshen injection, etc., but most of them are early injection products, the quality control is not ideal, and the curative effect is average. Adverse reactions often occur clinically, and the use is obviously restricted

Method used

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  • Medicine for treating cerebral infarction, coronary heart disease and angina pectoris
  • Medicine for treating cerebral infarction, coronary heart disease and angina pectoris

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Taking the production of 1000 freeze-dried powder injections of the present invention as an example, the used crude drug and auxiliary materials and their weight ratios are:

[0035] Panax notoginseng 2000g

[0036] Radix Paeoniae Alba 500g

[0037] Mannitol 110g

[0038] Its preparation method is as follows:

[0039] Take notoginseng medicinal material, crush it, pass through a 40-mesh sieve, extract 3 times with 75% ethanol, the extraction time is 2 hours, and the amount of ethanol is 10 times the amount, combine the three extracts, filter, recover the ethanol until nearly dry, press water and soak The weight ratio of the paste is 10:1, add water to dissolve it, let it stand, filter, and move the filtrate into the treated D 101 In the macroporous adsorption resin column, first wash with water until the effluent is colorless, discard the washing liquid, and then elute with 75% ethanol, collect the eluate, recover ethanol, concentrate to a relative density of 1.25 (6...

Embodiment 2

[0060] Taking the production of 1000 freeze-dried powder injections of the present invention as an example, the used crude drug and auxiliary materials and their weight ratios are:

[0061] Panax notoginseng 1667g

[0062] Paeoniae Rubra 833g

[0063] Mannitol 110g

[0064] Its preparation method is carried out according to the preparation method of the freeze-dried powder injection of the present invention. Each stick weighs 220mg, and each gram contains 11.364g of traditional Chinese medicine raw materials.

[0065] Usage and dosage: dissolved in 250ml normal saline or 5% glucose injection for intravenous drip. Adults take 1 to 2 sticks each time, once a day.

[0066] Taking the production of 1000 tablet products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0067] Panax notoginseng 555g

[0068] Radix Paeoniae Alba 278g

[0069] Add starch to 400g

[0070] Its preparation ...

Embodiment 3

[0082] Taking the production of 1000 freeze-dried powder injections of the present invention as an example, the used crude drug and auxiliary materials and their weight ratios are:

[0083]Panax notoginseng 2143g

[0084] Radix Paeoniae Alba 357g

[0085] Mannitol 110g

[0086] Its preparation method is carried out according to the preparation method of the freeze-dried powder injection of the present invention. Each stick weighs 220mg, and each gram contains 11.364g of traditional Chinese medicine raw materials.

[0087] Usage and dosage: dissolved in 250ml normal saline or 5% glucose injection for intravenous drip. Adults take 1 to 2 sticks each time, once a day.

[0088] Taking the production of 1000 tablet products of the present invention as an example, the used Chinese medicine raw materials and auxiliary materials and their proportioning ratio are:

[0089] Panax notoginseng 714g

[0090] Radix Paeoniae Alba 119g

[0091] Add starch to 400g

[0092] Its preparat...

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Abstract

The medicine for treating cerebral infarction, coronary heart disease and angina pectoris is prepared with red peony root in 1 weight portions and notoginseng in 2-6 weight portions as material. Animal experiments show that the medicine of the present invention can reduce cerebral infarction area, increase cerebral flow, reduce cerebral vascular resistance, resist acute myocardial ischemia, increase blood flow of coronary artery, reduce thromosis, lower fibrinogen, blood viscosity, etc.

Description

technical field [0001] The invention belongs to the technical field of medical preparations containing raw materials or their reaction products with unknown structures, and specifically relates to materials derived from plants. Background technique [0002] Cerebrovascular disease is one of the three major causes of death in the elderly, among which acute ischemic cerebrovascular disease accounts for 43% to 65% of cerebrovascular diseases, and the fatality rate is 15% to 25%. 43% to 65%. It is not only a medical problem, but also brings misfortune and pain to patients and families. It can be seen that cerebral infarction is a common and frequently-occurring disease that endangers middle-aged and elderly people, and has the characteristics of high incidence, high disability rate, and high recurrence rate. [0003] Coronary heart disease and angina pectoris belong to the category of "chest pain" in traditional Chinese medicine. After the 1950s, coronary heart disease has bec...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/258A61K9/08A61K9/16A61K9/20A61K9/48A61P9/10
Inventor 马耀茹李德友
Owner 马耀茹
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