Series medicament of zanthoxylum bungeanum seed kernel oil and ligusticum wallichiil alkaloid and preparing process thereof

Abstract

The present invention relates to a Chinese medicine preparation for curing angiocardiopathy and cerebrovascular disease, said Chinese medicine can be made into oral liquor, tablet and capsule preparation, and its effective prescription is formed from xanthoxylum seed oil and ligusticum alkaloid. Said invented medicine preparation can obtain obvious therapeutic effect, and said invention also provides its preparation method and concrete steps.

Description

Technical field: [0001] The present invention combines pepper seed germ kernel oil and Chuanxiong alkaloids and its preparation process, which belong to the medicine for treating cardiovascular and cerebrovascular diseases and its preparation process, and especially relates to the preparation of traditional Chinese medicine compound preparations and its series of products that are combined with Chinese medicinal materials craft. Background technique [0002] The treatment, prevention and drug development of cardiovascular and cerebrovascular diseases represented by hypertension, coronary heart disease and cerebral thrombosis are the focus of the modernization of traditional Chinese medicine at home and abroad. The main Chinese medicinal materials used in traditional medicine are salvia miltiorrhiza, ginkgo, kudzu root, chuanxiong, hair holly, hawthorn , safflower, perilla, seabuckthorn, flax, amaranthus, etc., but the content of its medicinal ingredients is low, low curative...

AI Technical Summary

Problems solved by technology

[0002] The treatment, prevention and drug development of cardiovascular and cerebrovascular diseases represented by hypertension, coronary heart disease and cerebral thrombosis are the focus of the modernization of traditional Chinese medicine at home and abroad. The main Chinese medicinal materials used in traditional medicine are salvia miltiorrhiza, ginkgo, kudzu root, chuanxiong, hair holly, hawthorn , safflower, perilla, seabuckthorn, flax, amaranthus, etc., but the content of its medicinal ingredients is low, low curative effect and repeated prescription drug development, especially traditional Chinese patent medicines with more repeated dosage forms, high production costs , the price is expensive, and the economic burden of long-term use is very heavy for patients. Because the treatment range is narrow and the curative effect is not outstanding, it is difficult to adapt to the selection of patients with different cardiovascular and cerebrovascular diseases.

Since it was confirmed that α-linolenic acid can generate EPA (20:5N-3) and DHA (22:6N-3) through dehydrogenation in the human body, domestic and foreign medicinal materials rich in α-linolenic acid, safflower, purple Extracting fatty acid oil from plant seeds such as perilla and seabuckthorn to replace deep-sea fish oil to develop new drugs for treating cardiovascular and cerebrovascular diseases has once become a hot topic, but according to "Modern Research and Clinical Application of Traditional Chinese Medicine" published by Xueyuan Press in October 1993 Relevant information on pages 332, 378 and 633 of the book confirms that safflower extract has obvious mutagenic effect, seabuckthorn oil and total flavonoids of seabuckthorn have strong cumulative toxicity, perilla contains toxic eugenol , α-pinene, and perillyl alcohol, the toxic and side effects have become obstacles to the development of new national traditional Chinese medicines from the effective parts of the above-mentioned Chinese medicinal materials