Flunarizine hydro chloride high-capacity injecta and preparing process thereof

Abstract

The present invention provides a flunarizine hydrochloride bulk injection and its production process. Its preparation range, every ampule contains 2mg-50mg of flunarizine hydrochloride and 0.1 ml-10 ml of 1.2-propylene glycol, the solvent respectively can be glucose, sodium chloride and glucose sodium chloride, and their contents respectively are 1g-50g of glucose and 0.3g-10g of sodium chloride. Its production process includes the following steps: placing 20ml of 1.2-propylene glycol in a container, then adding flunarizine hydrochloride, in said container, heating, stirring and dissolving; using injection water to dissolve glucose, stirring, adding it into container, diluting and dissolving, adding injection water to full dose, adding active carbon, heating to 80-90 deg.C, heat-insulating for 15 min., filtering and removing carbon, secondary filtering, adding flurnarizine hydrochloride and 1.2-propylene glycol mixed liquor, stirring them uniformly, regulating pH to 3.5-5.0 so as to obtain the invented product.

Description

Technical field: [0001] The invention belongs to the technical field of western medicine, is an intravenous infusion medicine for treating cardiovascular and cerebrovascular diseases, and relates to a large-capacity flunarizine hydrochloride injection and a processing technology thereof. Background technique: [0002] Existing flunarizine hydrochloride has oral dosage forms (tablets, capsules) not only have low bioavailability, slow absorption, it is very difficult to use for critically ill patients and patients with oral insomnia; flunarizine hydrochloride small needle for muscle Injection, injection pain, slow onset of action, low bioavailability, inconvenient use and incompatibility should be considered. Invention content: [0003] The object of the present invention is to provide a flunarizine hydrochloride large-capacity injection with quick onset, high bioavailability, convenient use and no need to consider incompatibility and its processing technology. [0004] The...

AI Technical Summary

Problems solved by technology

[0002] Existing flunarizine hydrochloride has oral dosage forms (tablets, capsules) not only have low bioavailability, slow absorption, it is very difficult to use for critically ill patients and patients with oral insomnia; flunarizine hydrochloride small needle for muscle Injection, injection pain, slow onset of action, low bioavailability, inconvenient use, and incompatibility needs to be considered