Arginine acetate oral preparation and clinical application thereof

Abstract

The present invention belongs to non-specific immunoenhancing drugs, which is an oral preparation of arginine acetate. Road will not produce irritation, long-term use will not produce hyperchloremia. As an immune-enhancing drug, it is mainly used clinically for patients with severe trauma, burns, major surgery, and cancer patients whose immune function is suppressed after radiotherapy and chemotherapy. It is safe, convenient, and effective.

Description

1. Technical field [0001] The invention belongs to medicaments, in particular to a medicament with non-specific immune enhancing effect. 2. Background technology [0002] Arginine is a conditionally essential amino acid, which can improve the immune function of the body, promote protein synthesis, reduce catabolism, and protect the gastrointestinal mucosa. It is currently a focus of research in "Nutritional Pharmacology". Studies have found that arginine can improve protein metabolism in burn rats and promote wound healing. Intestinal supplementation of arginine in burn patients can reduce the degree of intestinal damage after burn, improve immune function, and shorten hospitalization time. At present, the commercially available arginine for treatment at home and abroad has only two kinds of L-arginine and arginine hydrochloride; but they are used as raw materials to prepare preparations for oral administration, and there are following defects: L-arginine base It is strong...

AI Technical Summary

Problems solved by technology

At present, the commercially available arginine for treatment at home and abroad has only two kinds of L-arginine and arginine hydrochloride; but they are used as raw materials to prepare preparations for oral administration, and there are following defects: L-arginine base It is strong in nature, and its pH is between 10.5 and 12.0. After oral administration, it stimulates the gastrointestinal tract strongly, which will cause symptoms of stomach discomfort, and long-term large-scale application can affect the pH value of blood, while arginine hydrochloride is acidic, and its pH is between 4.7-6.2, and the content of chloride ion is high, reaching 16.5%-17.1%. After oral administration, it also stimulates the gastrointestinal tract to a certain extent, which will not only cause stomach discomfort, but also cause metabolic acidosis and hyperchloremia if used for a long time

After literature search, only the 13th edition of the Japanese Pharmacopoeia, the 23rd edition of the United States Pharmacopoeia and the 2000 edition of the Chinese Pharmacopoeia contained arginine hydrochloride and its injection; no literature reports on oral preparations of arginine acetate have been seen