Arginine acetate oral preparation and clinical application thereof

Abstract

The present invention relates to a nonspecific immunoenhancement medicine, and it is an arginine acetate oral preparation, its medicinal effect component is agrinine acetate, its pH value is 6.0-7.5,and it has no chloride ion acid radical, after it is taken in, it does not produce irritation to gastrointestinal tract, and it can be taken in for a long period, it also does not produce hyperchloremia, and it is mainly used for curing serious burn and serious scald, and for making auxiliary therapy of tumor patient and patient after major operation.

Description

1. Technical Field [0001] The invention belongs to a medicine, and specifically relates to a medicine with a non-specific immune enhancement effect. 2. Background technology [0002] Arginine is a conditional essential amino acid. It can improve the body's immune function, promote protein synthesis, reduce catabolism, and protect the gastrointestinal mucosa. It is currently a focus of research on nutritional pharmacology. Studies have found that arginine can improve protein metabolism in burn rats and promote wound healing. Intestinal supplementation of arginine for burn patients can reduce the degree of intestinal damage after burns, improve immune function, and shorten the length of hospitalization. At present, there are only two kinds of arginine that are commercially available for treatment at home and abroad, L-arginine and arginine hydrochloride; but using them as raw materials to prepare oral preparations has the following defects: L-arginine base Strong sex, pH is 10.5~12...

AI Technical Summary

Problems solved by technology

At present, the commercially available arginine for treatment at home and abroad has only two kinds of L-arginine and arginine hydrochloride; but they are used as raw materials to prepare preparations for oral administration, and there are following defects: L-arginine base It is strong in nature, and its pH is between 10.5 and 12.0. After oral administration, it stimulates the gastrointestinal tract strongly, which will cause symptoms of stomach discomfort, and long-term large-scale application can affect the pH value of blood, while arginine hydrochloride is acidic, and its pH is between 4.7-6.2, and the content of chloride ion is high, reaching 16.5%-17.1%. After oral administration, it also stimulates the gastrointestinal tract to a certain extent, which will not only cause stomach discomfort, but also cause metabolic acidosis and hyperchloremia if used for a long time

After literature search, only the 13th edition of the Japanese Pharmacopoeia, the 23rd edition of the United States Pharmacopoeia and the 2000 edition of the Chinese Pharmacopoeia contained arginine hydrochloride and its injection; no literature reports on oral preparations of arginine acetate have been seen