Refapentine or rifampin liposome perfusate, injection and preparation process thereof
A technology of rifampicin lipid and rifapentine, applied in the field of liposome solution, can solve the problems of few effective treatment methods, difficult clinical treatment of pulmonary tuberculosis, insufficient dispersion of emulsion, etc. The effect of significant treatment effect and shortened treatment period
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Embodiment 1
[0094] Rifapentine or rifampicin liposome microemulsion formula, the weight ratio of each component is:
[0095] Rifapentine / rifampicin 3.5
[0096] Lecithin 5.0
[0097] Cholesterol 3.0
[0098] Lauroyl diethanolamine 0.5
[0099] Distilled water 88.
[0100] Preparation:
[0101] Accurately weigh rifapentine (rifampicin), lecithin, cholesterol, and lauroyl diethanolamine and place them in a round-bottomed flask, add chloroform and absolute ethanol, and oscillate to fully dissolve each component to form a red transparent solution. Water bath at 50°C, vacuumize, and distill to remove the solvent, so that lecithin, cholesterol and drugs form a thin film on the bottle wall. Add a little distilled water to make the film wet and swell, stir quickly to make the film fall off and dissolve, add medical distilled water to become a translucent solution. The solution was poured out, and the flask was washed several times with the remaining distilled water. The resulting solutions we...
Embodiment 2
[0104] Rifapentine or rifampicin composite drug liposome microemulsion formula, the weight ratio of each component is:
[0105] Rifapentine / rifampicin 3.5
[0106] Ofloxacin 2.0
[0107] Lecithin 4.0
[0108] Cholesterol 3.0
[0109] Lauroyl diethanolamine 3.5
[0110] distilled water 84.
[0111] Preparation:
[0112] Accurately weigh rifapentine, ofloxacin, lecithin, cholesterol, and lauroyl diethanolamine into a round-bottomed flask, add chloroform and absolute ethanol, and oscillate to fully dissolve each component to form a red transparent solution. Water bath at 50°C, vacuumize, and distill to remove the solvent, so that lecithin, cholesterol and drugs form a thin film on the bottle wall. Add a little distilled water to make the film wet and swell, stir quickly to make the film fall off and dissolve, then add distilled water to become a translucent solution. The solution was poured out, and the flask was washed several times with the remaining distilled water. The...
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